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导师基本信息

  • 姓名:季加孚
  • 性别:
  • 民族:汉族
  • 科室:胃肠肿瘤中心一病区
  • 职称:主任医师 ,教授
  • 专业:肿瘤学
  • E-MAIL: jiafuj@hotmail.com

研究方向

胃癌围手术期综合治疗的临床研究(规范化手术、新辅助治疗、转化医学)

胃癌生物学行为判断分子标志谱的建立(高通量生物芯片、数据库的建立、临床样本的测试)

发表学术论文| 出版的专著| 获得的成果、奖励| 招生记录

Ji X#, Bu ZD#, Li ZY, Wu AW, Zhang LH, Zhang J, Wu XJ, Zong XL, Li SX, Shan F, Jia ZY, Ji JF*.Prognostic significance of the total number of harvested lymph nodes for lymph node-negative gastric cancer patients BMC Cancer ,2017;17(1):558

Wang S#, Han H#, Hu Y#, Yang W, Lv Y, Wang L*, Zhang L*, Ji J* SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer Oncotarget ,2017,8(51):88586-88598.

Xie M, Dart DA, Guo T, Xing XF, Cheng XJ, Du H, Jiang WG, Wen XZ, Ji JF* MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer Gastric Cancer ,2017;epub

The optimal extent of gastrectomy for middle-third gastric cancer: distal subtotal gastrectomy is superior to total gastrectomy in short-term effect without sacrificing long-term survival BMC Cancer ,2017;17(1):345

Ma M, Zhuang F, Hu X, Wang B, Wen XZ, Ji JF*, Xi JJ, Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system Cell Res ,2017;27(4):578-581

郑楠,徐国兵,季加孚* A sensitive liquid chromatography/electrospray tandem mass spectroscopy method for simultaneous quantification of a disulfide bond doxorubicin conjugation prodrug and activated doxorubicin: Application to cellular pharmacokinetic and catabolism studies. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences ,2017;1065-1066:96-103

Hu Y, Han H, Wang Y, Song L, Cheng X, Xing X, Dong B, Wang X, Chen M, Zhang L*, Ji J*. Influence of Freeze-Thaw Cycles on RNA Integrity of Gastrointestinal Cancer and Matched Adjacent Tissues BIOPRESERVATION AND BIOBANKING ,2017;15(3):241-247

Clinical Correlation Between WISP2 and beta-Catenin in Gastric Cancer ANTICANCER RESEARCH ,2017;37(8):4469-4473

Jia S*, Qu T, Wang X, Feng M, Yang Y, Feng X, Ma R, Li W, Hu Y, Feng Y, Ji K, Li Z, Jiang W, Ji J* KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer PLoS One ,2017; 12(4): e0175058

Wang XH, Du H, Li L, Shao DF, Zhong XY, Hu Y, Liu YQ, Xing XF, Cheng XJ, Guo T, Li S, Li ZY, Bu ZD, Wen XZ, Zhang LH*, Ji JF*.Increased expression of S100A6 promotes cell proliferation in gastric cancer cells Oncol Lett ,2017;13(1):222-230

Jia S, Qu T, Feng M, Ji K, Li Z, Jiang W*, Ji J*. Association of Wnt1-inducible signaling pathway protein-1 with the proliferation, migration and invasion in gastric cancer cells. Tumor Biology ,2017;39(6):1-9

Jia S*, Lu J, Qu T, Feng Y, Wang X, Liu C, Ji J*. MAGI1 inhibits migration and invasion via blocking MAPK/ERK signaling pathway in gastric cancer Chin J Cancer Res ,2017;29(1):25-35

Xing X,, Jia S, Wu J, Feng Q, Dong B, Li B, Jia Y,Shan F, Li Y, Zhang Y, Hu Y, Wang X, Liu X, Yu W, Zhang L, Bu Z, Wu A, Li Z*, Ji J*, Clonality analysis of synchronous gastroesophageal junction carcinoma and distal gastric cancer by whole-exome sequencing J Pathol ,2017;243(2):165-175

Wang X, Fu R, Hu Y, Du H, Li S, Li Z, Liu Y, Li Q, Zhang L, Ji J. EGFR gene status predicts response and survival benefit in a preclinical gastric cancer trial treating patient‑derived xenografts with cetuximab ONCOLOGY REPORTS ,2017;38(4):2387-2393

Wang X#, Liu Y#, Niu Z#, Fu R#, Jia Y, Zhang L, Shao D, Du H, Hu X, Xing X, Cheng X, Li L, Guo T4, Li Z, Ji Q, Zhang L*, Ji J*. Prognostic value of a 25-gene assay in patients with gastric cancer after curative resection SCIENTIFIC REPORTS ,2017;7(1):7515

Li Z, Shan F, Wang Y, Li S, Jia Y, Zhang L, Yin D, Ji J. Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: safety and short-term oncologic results. Surgical Endoscopy and other interventional techniques ,2016 Oct;30(10):4265-71. doi: 10.1007/s00464-015-4739-z. Epub 2016 Jun 10.

Cheng X, Tian X, Wu X, Xing X, Du H, Zhou C, Zhang Q, Hao C, Wen X, Ji J. Relationship between LAPTM4B Gene Polymorphism and Prognosis of Patients following Tumor Resection for Colorectal and Esophageal Cancers. PLoS One. ,2016 Jul 8;11(7):e0158715. doi: 10.1371/journal.pone.0158715. eCollection 2016.

Li Z, Ao S, Bu Z, Wu A, Wu X, Shan F, Ji X, Zhang Y, Xing Z, Ji J*. Clinical study of harvesting lymph nodes with carbon nanoparticles in advanced gastric cancer: a prospective randomized trial. World J Surg Oncol. ,Mar 24;14(1):88. doi: 10.1186/s12957-016-0835-3.

Zheng Z, Zhang Y, Zhang L, Li Z, Wu X, Liu Y, Bu Z, Ji J*. A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients. BMC Cancer. ,Feb 12;16:92. doi: 10.1186/s12885-016-2132-5.

Zhang L, Wu X, Hu Y, Wang X, He Z, Xie Y, Pan K, Wang N, Dong Z, Zhang L, Ji J*. Establishment of a network-based intra-hospital virtual cancer biobank. Biopreserv Biobank. ,Feb;13(1):43-8. doi: 10.1089/bio.2014.0086.

Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J*, Ji Q. Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets. Genes Chromosomes Cancer ,53(11):883-94. doi: 10.1002/gcc.22196. Epub 2014 Jun 17

Wu A, Jia Y, Dong B, Tang L, Liu Y, Du H, Yuan P, Dong P, Ji J*. Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy. Cancer Chemother Pharmacol. ,73(5):885-93. doi: 10.1007/s00280-014-2410-3.

Zheng Z, Liu Y, Bu Z, Zhang L, Li Z, Du H, Ji J*. Prognostic role of lymph node metastasis in early gastric cancer. Chin J Cancer Res. ,26(2):192-9. doi: 10.3978/j.issn.1000-9604.

Gao T, Han Y, Yu L, Ao S, Li Z, Ji J*. CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance. PLoS One. ,9(3):e91771. doi: 10.1371/journal.pone.0091771.

Shan F, Miao R, Xue K, Li Z, Li Z, Bu Z, Wu A, Zhang L, Wu X, Zong X, Wang X, Li S, Ji X, Jia Z, Li Z, Ji J*. Controlling angiogenesis in gastric cancer: A systematic review of anti-angiogenic trials. Cancer Lett. ,Dec 24. pii: S0304-3835(15)00774-0. doi: 10.1016/j.canlet.2015.12.023.

Zheng Z, Zhang Y, Zhang L, Li Z, Wu A, Wu X, Liu Y, Bu Z, Ji J#. Nomogram for predicting lymph node metastasis rate of submucosal gastric cancer by analyzing clinicopathological characteristics associated with lymph node metastasis. Chin J Cancer Res. ,Dec;27(6):572-9. doi: 10.3978/j.issn.1000-9604.2015.12.06.

Wu X, Li Z, Li Z, Jia Y, Shan F, Ji X, Bu Z, Zhang L, Wu A, Ji J*. Hyperthermic intraperitoneal chemotherapy plus simultaneous versus staged cytoreductive surgery for gastric cancer with occult peritoneal metastasis. J Surg Oncol. ,Jun;111(7):840-7. doi: 10.1002/jso.23889. Epub 2015 Apr 10.

Zhang L, Liu Y, Wang X, Tang Z, Li S, Hu Y, Zong X, Wu X, Bu Z, Wu A, Li Z, Li Z, Huang X, Jia L, Kang Q, Liu Y, Sutton D, Wang L, Luo L, Ji J*. The extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice. Sci Rep. ,Mar 30;5:9447. doi: 10.1038/srep09447.

Ji J, Jia S, Ji K, Jiang WG. Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review). Oncol Rep. . ,31(2):533-9. doi: 10.3892/or.2013.2909. Epub 2013 Dec 9

Zheng Z, Bu Z, Liu X, Zhang L, Li Z, Wu A, Wu X, Cheng X, Xing X, Du H, Wang X, Hu Y, Ji J*. Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications. Chin J Cancer Res. ,2014 Feb;26(1):104-11. doi: 10.3978/j.issn.1000-9604.

Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J, Han W. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer. Cancer Sci. ,2014 Jan;105(1):26-34. doi: 10.1111/cas.12304. Epub 2013 Nov 28.

Yan, Y., Z. Li, Y. Liu, L. Zhang, J. Li, and J. Ji, Coexistence of gastrointestinal stromal tumors and gastric adenocarcinomas. Tumour Biol ,34(2):919-27.

Bu, Z., Z. Zheng, Z. Li, L. Zhang, A. Wu, X. Wu, Y. Sun, and J. Ji, Lymphatic vascular invasion is an independent correlated factor for lymph node metastasis and the prognosis of resectable T2 gastric cancer patients. Tumor Biol ,34(2):1005-12.

Wu, X.J., P. Yuan, Z.Y. Li, Z.D. Bu, L.H. Zhang, A.W. Wu, X.L. Zong, S.X. Li, F. Shan, X. Ji, H. Ren, and J.F. Ji, Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves the survival of gastric cancer patients with ovarian metastasis and peritoneal dissemination. Tumor Biol ,34(1):463-9.

Lin, Y., L.H. Zhang, X.H. Wang, X.F. Xing, X.J. Cheng, B. Dong, Y. Hu, H. Du, Y.A. Li, Y.B. Zhu, N. Ding, Y.X. Du, J.Y. Li, and J.F. Ji, PTK7 as a novel marker for favorable gastric cancer patient survival. J Surg Oncol ,106(7): p. 880-6.

Jia, Y., B. Dong, L. Tang, Y. Liu, H. Du, P. Yuan, A. Wu, and J. Ji, Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer. Tumor Biol ,33(4): p. 1151-8.

Fan, B., L.H. Zhang, Y.N. Jia, X.Y. Zhong, Y.Q. Liu, X.J. Cheng, X.H. Wang, X.F. Xing, Y. Hu, Y.A. Li, H. Du, W. Zhao, Z.J. Niu, A.P. Lu, J.Y. Li, et al., Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer. BMC Cancer ,12:316. doi: 10.1186/1471-2407-12-316.

Li, Z.Y., C.E. Koh, Z.D. Bu, A.W. Wu, L.H. Zhang, X.J. Wu, Q. Wu, X.L. Zong, H. Ren, L. Tang, X.P. Zhang, J.Y. Li, Y. Hu, L. Shen, and J.F. Ji, Neoadjuvant chemotherapy with FOLFOX: improved outcomes in Chinese patients with locally advanced gastric cancer. J Surg Oncol ,105(8): p. 793-9.

Fan, B., S. Dachrut, H. Coral, S.T. Yuen, K.M. Chu, S. Law, L. Zhang, J. Ji, S.Y. Leung, and X. Chen, Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer. PLoS One ,7(4): p. e29824.

张连海,牛兆建,仲西瑶,刘毅强,李子禹,季加孚*. 利用组织芯片研究Fascin在食管癌中的表达. 中国临床医学 ,13(6):924-926

Hao CY, Lu AP, Xing BC, Huang XF, Gao F, Ji JF*. Solid pseudopapillary tumor of the pancreas: report of 8 cases in a single institution and review of the Chinese literature. Pancreatology. ,6(4):291-296

社会任职

  • 胃癌协作中心首席专家
  • 教育部恶性肿瘤发病机制及转化重点实验室胃癌研究室主任
  • 亚洲外科学会(ASA)常委
  • 国际外科医师暨胃肠道医师协会(IASGO)学术委员会委员
  • 欧洲临床营养与代谢学会(ESPEN)会员
  • 欧洲IASGO学院外科学客座教授
  • 中国抗癌协会胃癌专业委员会主任委员
  • CSCO肿瘤营养治疗专家委员会副主任委员
  • 中国医药生物技术协会组织生物样本库分会委员
  • 卫生部海峡两岸医药交流协会肿瘤健康体检专家委员会主任委员
  • 美国外科学会(ACS)会员
  • 老年学学会老年肿瘤专业委员会执行委员会常委
  • 《消化肿瘤杂志》副主编
  • 《中华医学杂志》编委
  • 《中华胃肠外科杂志》编委
  • 《中华外科杂志》编委
  • 《中国实用外科杂志》编委
  • 《临床肿瘤学杂志》编委
  • 《临床肿瘤学进展》编委
  • 《中国普外基础与临床杂志》编委
  • 《医学研究杂志》编委
  • 《医学新知杂志》编委
  • 《Digestive Surgery》Editorial Board Member
  • 《中华普外科手术学杂志(电子版)》常务编委
  • 《World Journal of Gastrointestinal Pathophysiology》Editorial Board Member
  • 《中华消化外科杂志》编委
  • 《 World Journal of Gastroenterology》Editorial Board Member
  • 《Annals of Surgery》Editorial Board Member
  • 国家自然基金和“863”重点项目评审专家
  • 北京医学会、中华医学会医疗事故鉴定专家
  • 国家临床重点专科评估评审专家
  • 民盟中央委员,民盟北京大学医学部主委
  • 北京市第十届、十一届政协委员

学习、工作经历

  • 2011.7.1~2017.6.21,北京市肿瘤防治研究所所长
  • 2016.6.21~2017.6.21,北京大学肿瘤研究中心主任
  • 2015.6.21~2017.6.21,教育部恶性肿瘤发病机制及转化中心主任
  • 2007.2.14~2080.6.14,北京肿瘤医院 生物样本库主任
  • 2015.11.3~2080.6.14,北京肿瘤医院 分子诊断中心主任
  • 2015.5.16~2080.6.14,北京肿瘤医院 胃肠肿瘤中心主任
  • 1999.1.14~2000.3.14,美国斯坦福大学医学院 博士后
  • 2011.7.1~2080.6.14,北京肿瘤医院 院长、大外科主任
  • 2002.8.1~2080.6.14,北京肿瘤医院 胃肠外科主任
  • 2002.8.1~2080.6.14,北京肿瘤医院 副教授、教授
  • 2001.8.1~2080.6.14,北京肿瘤医院 主任医师
  • 1990.1.14~2000.3.14,美国斯坦福大学 访问学者
  • 1995.6.14~2001.7.14,北京肿瘤医院 副主任医师
  • 1990.8.14~1995.5.14,北京肿瘤医院 医师、主治医师
  • 1982.12.14~1987.8.14,内蒙古医学院第一附属医院 医师
  • 1978.3.14~1982.12.14,内蒙古医学院 学士
  • 1987.9.1~1990.7.14,北京医科大学 硕士