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导师基本信息

  • 姓名:季加孚
  • 科室:胃肠肿瘤中心一病区
  • 职称:主任医师
  • 专业:肿瘤学
  • E-MAIL: jiafuj@hotmail.com

研究方向

胃癌围手术期综合治疗的临床研究(规范化手术、新辅助治疗、转化医学)

胃癌生物学行为判断分子标志谱的建立(高通量生物芯片、数据库的建立、临床样本的测试)

发表学术论文| 出版的专著| 获得的成果、奖励

Wang X#, Liu Y#, Niu Z#, Fu R#, Jia Y, Zhang L, Shao D, Du H, Hu X, Xing X, Cheng X, Li L, Guo T4, Li Z, Ji Q, Zhang L*, Ji J*. Prognostic value of a 25-gene assay in patients with gastric cancer after curative resection

Wang X, Fu R, Hu Y, Du H, Li S, Li Z, Liu Y, Li Q, Zhang L, Ji J. EGFR gene status predicts response and survival benefit in a preclinical gastric cancer trial treating patient‑derived xenografts with cetuximab

Xing X,, Jia S, Wu J, Feng Q, Dong B, Li B, Jia Y,Shan F, Li Y, Zhang Y, Hu Y, Wang X, Liu X, Yu W, Zhang L, Bu Z, Wu A, Li Z*, Ji J*, Clonality analysis of synchronous gastroesophageal junction carcinoma and distal gastric cancer by whole-exome sequencing

Jia S*, Lu J, Qu T, Feng Y, Wang X, Liu C, Ji J*. MAGI1 inhibits migration and invasion via blocking MAPK/ERK signaling pathway in gastric cancer

Jia S, Qu T, Feng M, Ji K, Li Z, Jiang W*, Ji J*. Association of Wnt1-inducible signaling pathway protein-1 with the proliferation, migration and invasion in gastric cancer cells.

Wang XH, Du H, Li L, Shao DF, Zhong XY, Hu Y, Liu YQ, Xing XF, Cheng XJ, Guo T, Li S, Li ZY, Bu ZD, Wen XZ, Zhang LH*, Ji JF*.Increased expression of S100A6 promotes cell proliferation in gastric cancer cells

Jia S*, Qu T, Wang X, Feng M, Yang Y, Feng X, Ma R, Li W, Hu Y, Feng Y, Ji K, Li Z, Jiang W, Ji J* KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer

Clinical Correlation Between WISP2 and beta-Catenin in Gastric Cancer

Hu Y, Han H, Wang Y, Song L, Cheng X, Xing X, Dong B, Wang X, Chen M, Zhang L*, Ji J*. Influence of Freeze-Thaw Cycles on RNA Integrity of Gastrointestinal Cancer and Matched Adjacent Tissues

郑楠,徐国兵,季加孚* A sensitive liquid chromatography/electrospray tandem mass spectroscopy method for simultaneous quantification of a disulfide bond doxorubicin conjugation prodrug and activated doxorubicin: Application to cellular pharmacokinetic and catabolism studies.

Ma M, Zhuang F, Hu X, Wang B, Wen XZ, Ji JF*, Xi JJ, Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system

The optimal extent of gastrectomy for middle-third gastric cancer: distal subtotal gastrectomy is superior to total gastrectomy in short-term effect without sacrificing long-term survival

Xie M, Dart DA, Guo T, Xing XF, Cheng XJ, Du H, Jiang WG, Wen XZ, Ji JF* MicroRNA-1 acts as a tumor suppressor microRNA by inhibiting angiogenesis-related growth factors in human gastric cancer

Wang S#, Han H#, Hu Y#, Yang W, Lv Y, Wang L*, Zhang L*, Ji J* SLC3A2, antigen of mAb 3G9, promotes migration and invasion by upregulating of mucins in gastric cancer

Ji X#, Bu ZD#, Li ZY, Wu AW, Zhang LH, Zhang J, Wu XJ, Zong XL, Li SX, Shan F, Jia ZY, Ji JF*.Prognostic significance of the total number of harvested lymph nodes for lymph node-negative gastric cancer patients

Wu, X.J., P. Yuan, Z.Y. Li, Z.D. Bu, L.H. Zhang, A.W. Wu, X.L. Zong, S.X. Li, F. Shan, X. Ji, H. Ren, and J.F. Ji, Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves the survival of gastric cancer patients with ovarian metastasis and peritoneal dissemination.

Bu, Z., Z. Zheng, Z. Li, L. Zhang, A. Wu, X. Wu, Y. Sun, and J. Ji, Lymphatic vascular invasion is an independent correlated factor for lymph node metastasis and the prognosis of resectable T2 gastric cancer patients.

Yan, Y., Z. Li, Y. Liu, L. Zhang, J. Li, and J. Ji, Coexistence of gastrointestinal stromal tumors and gastric adenocarcinomas.

Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J, Han W. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.

Zheng Z, Bu Z, Liu X, Zhang L, Li Z, Wu A, Wu X, Cheng X, Xing X, Du H, Wang X, Hu Y, Ji J*. Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications.

Ji J, Jia S, Ji K, Jiang WG. Wnt1 inducible signalling pathway protein-2 (WISP‑2/CCN5): roles and regulation in human cancers (review).

Gao T, Han Y, Yu L, Ao S, Li Z, Ji J*. CCNA2 is a prognostic biomarker for ER+ breast cancer and tamoxifen resistance.

Zheng Z, Liu Y, Bu Z, Zhang L, Li Z, Du H, Ji J*. Prognostic role of lymph node metastasis in early gastric cancer.

Wu A, Jia Y, Dong B, Tang L, Liu Y, Du H, Yuan P, Dong P, Ji J*. Apoptosis and KI 67 index correlate with preoperative chemotherapy efficacy and better predict the survival of gastric cancer patients with combined therapy.

Qian Z, Zhu G, Tang L, Wang M, Zhang L, Fu J, Huang C, Fan S, Sun Y, Lv J, Dong H, Gao B, Su X, Yu D, Zang J, Zhang X, Ji J*, Ji Q. Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.

Zhang L, Wu X, Hu Y, Wang X, He Z, Xie Y, Pan K, Wang N, Dong Z, Zhang L, Ji J*. Establishment of a network-based intra-hospital virtual cancer biobank.

Zhang L, Liu Y, Wang X, Tang Z, Li S, Hu Y, Zong X, Wu X, Bu Z, Wu A, Li Z, Li Z, Huang X, Jia L, Kang Q, Liu Y, Sutton D, Wang L, Luo L, Ji J*. The extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice.

Wu X, Li Z, Li Z, Jia Y, Shan F, Ji X, Bu Z, Zhang L, Wu A, Ji J*. Hyperthermic intraperitoneal chemotherapy plus simultaneous versus staged cytoreductive surgery for gastric cancer with occult peritoneal metastasis.

Zheng Z, Zhang Y, Zhang L, Li Z, Wu A, Wu X, Liu Y, Bu Z, Ji J#. Nomogram for predicting lymph node metastasis rate of submucosal gastric cancer by analyzing clinicopathological characteristics associated with lymph node metastasis.

Shan F, Miao R, Xue K, Li Z, Li Z, Bu Z, Wu A, Zhang L, Wu X, Zong X, Wang X, Li S, Ji X, Jia Z, Li Z, Ji J*. Controlling angiogenesis in gastric cancer: A systematic review of anti-angiogenic trials.

Zheng Z, Zhang Y, Zhang L, Li Z, Wu X, Liu Y, Bu Z, Ji J*. A nomogram for predicting the likelihood of lymph node metastasis in early gastric patients.

Li Z, Ao S, Bu Z, Wu A, Wu X, Shan F, Ji X, Zhang Y, Xing Z, Ji J*. Clinical study of harvesting lymph nodes with carbon nanoparticles in advanced gastric cancer: a prospective randomized trial.

Cheng X, Tian X, Wu X, Xing X, Du H, Zhou C, Zhang Q, Hao C, Wen X, Ji J. Relationship between LAPTM4B Gene Polymorphism and Prognosis of Patients following Tumor Resection for Colorectal and Esophageal Cancers.

Li Z, Shan F, Wang Y, Li S, Jia Y, Zhang L, Yin D, Ji J. Laparoscopic versus open distal gastrectomy for locally advanced gastric cancer after neoadjuvant chemotherapy: safety and short-term oncologic results.

Fan, B., S. Dachrut, H. Coral, S.T. Yuen, K.M. Chu, S. Law, L. Zhang, J. Ji, S.Y. Leung, and X. Chen, Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer.

Li, Z.Y., C.E. Koh, Z.D. Bu, A.W. Wu, L.H. Zhang, X.J. Wu, Q. Wu, X.L. Zong, H. Ren, L. Tang, X.P. Zhang, J.Y. Li, Y. Hu, L. Shen, and J.F. Ji, Neoadjuvant chemotherapy with FOLFOX: improved outcomes in Chinese patients with locally advanced gastric cancer.

Fan, B., L.H. Zhang, Y.N. Jia, X.Y. Zhong, Y.Q. Liu, X.J. Cheng, X.H. Wang, X.F. Xing, Y. Hu, Y.A. Li, H. Du, W. Zhao, Z.J. Niu, A.P. Lu, J.Y. Li, et al., Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer.

Jia, Y., B. Dong, L. Tang, Y. Liu, H. Du, P. Yuan, A. Wu, and J. Ji, Apoptosis index correlates with chemotherapy efficacy and predicts the survival of patients with gastric cancer.

Lin, Y., L.H. Zhang, X.H. Wang, X.F. Xing, X.J. Cheng, B. Dong, Y. Hu, H. Du, Y.A. Li, Y.B. Zhu, N. Ding, Y.X. Du, J.Y. Li, and J.F. Ji, PTK7 as a novel marker for favorable gastric cancer patient survival.

Hao CY, Lu AP, Xing BC, Huang XF, Gao F, Ji JF*. Solid pseudopapillary tumor of the pancreas: report of 8 cases in a single institution and review of the Chinese literature.

张连海,牛兆建,仲西瑶,刘毅强,李子禹,季加孚*. 利用组织芯片研究Fascin在食管癌中的表达.

社会任职

  • 国际胃癌学会(IGCA)主席
  • 中华医学会外科学会秘书长、中华医学会外科学会全国委员、国际合作部主任、胃肠专业委员会副主任委员
  • 中华医学会外科学分会 秘书长
  • 吴阶平基金会医疗大数据委员会副主任委员
  • 中国抗癌协会肿瘤医院(研究所)管理专业委员会候任主任委员
  • 北京市第十二届政协常委
  • 能量外科学院院长
  • 中国抗癌协会副理事长
  • 北京市第十届、十一届政协委员
  • 民盟中央委员,民盟北京大学医学部主委
  • 国家临床重点专科评估评审专家
  • 北京医学会、中华医学会医疗事故鉴定专家
  • 国家自然基金和“863”重点项目评审专家
  • 《Annals of Surgery》Editorial Board Member
  • 《 World Journal of Gastroenterology》Editorial Board Member
  • 《中华消化外科杂志》编委
  • 《World Journal of Gastrointestinal Pathophysiology》Editorial Board Member
  • 《中华普外科手术学杂志(电子版)》常务编委
  • 《Digestive Surgery》Editorial Board Member
  • 《医学新知杂志》编委
  • 《医学研究杂志》编委
  • 《中国普外基础与临床杂志》编委
  • 《临床肿瘤学进展》编委
  • 《临床肿瘤学杂志》编委
  • 《中国实用外科杂志》编委
  • 《中华外科杂志》编委
  • 《中华胃肠外科杂志》编委
  • 《中华医学杂志》编委
  • 《消化肿瘤杂志》副主编
  • 老年学学会老年肿瘤专业委员会执行委员会常委
  • 美国外科学会(ACS)会员
  • 卫生部海峡两岸医药交流协会肿瘤健康体检专家委员会主任委员
  • 中国医药生物技术协会组织生物样本库分会委员
  • CSCO肿瘤营养治疗专家委员会副主任委员
  • 中国抗癌协会胃癌专业委员会主任委员
  • 欧洲IASGO学院外科学客座教授
  • 欧洲临床营养与代谢学会(ESPEN)会员
  • 国际外科医师暨胃肠道医师协会(IASGO)学术委员会委员
  • 亚洲外科学会(ASA)常委
  • 教育部恶性肿瘤发病机制及转化重点实验室胃癌研究室主任
  • 胃癌协作中心首席专家

学习、工作经历

  • 2015.11~至今,北京肿瘤医院 分子诊断中心主任
  • 2015.5~至今,北京肿瘤医院 胃肠肿瘤中心主任
  • 2011.7~至今,北京肿瘤医院 院长、大外科主任
  • 2007.2~至今,北京肿瘤医院 生物样本库主任
  • 2002.8~至今,北京肿瘤医院 胃肠外科主任
  • 2002.8~至今,北京肿瘤医院 副教授、教授
  • 2001.8~至今,北京肿瘤医院 主任医师
  • 2011.7~2017.6,北京市肿瘤防治研究所所长
  • 2016.6~2017.6,北京大学肿瘤研究中心主任
  • 2015.6~2017.6,教育部恶性肿瘤发病机制及转化中心主任
  • 1995.6~2001.7,北京肿瘤医院 副主任医师
  • 1999.1~2000.3,美国斯坦福大学医学院 博士后
  • 1990.1~2000.3,美国斯坦福大学 访问学者
  • 1990.8~1995.5,北京肿瘤医院 医师、主治医师
  • 1987.9~1990.7,北京医科大学 硕士
  • 1982.12~1987.8,内蒙古医学院第一附属医院 医师
  • 1978.3~1982.12,内蒙古医学院 学士