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导师基本信息

  • 姓名:杨志
  • 性别:
  • 民族:汉族
  • 科室:核医学科
  • 职称:研究员
  • 专业:影像医学与核医学
  • E-MAIL: pekyz@13.com

学术论文 | 奖励表彰 | 专利 | 科研项目 | 招生计划

Qian Guo, Chuanke Zhao, Xiangyu Gao, Lixin Ding, Pei Wang, Ya'nan Ren, Xingguo Hou, Yuan Yao, Cheng Zhang*, Xianteng Yang*, Zhi Yang*, Hua Zhu*. One-Minute Iodine Isotope Labeling Technology Enables Noninvasive Tracking and Quantification of Extracellular Vesicles in Tumor Lesions and Intact Animals,molecular pharmaceutics,2023 May 22. doi: 10.1021/acs.molpharmaceut.3c00299

Xuetao Chen Tingting Yuan Maomao Wei Boqi Yu Nina Zhou Hua Zhu Zhi Yang* Xuejuan Wang*,Diagnostic performance of integrated whole-body 18F-FDG PET/MRI for detecting bone marrow involvement in indolent lymphoma: comparison with 18F-FDG PET or MRI alone,Frontiers in Oncology,2023 Mar 13;13:1136687

Xiao Jin#, Maomao Wei#, Shuailiang Wang#, Guochang Wang#, Yumei Lai, Yunfei Shi, Yan Zhang, Zhi Yang*, Xuejuan Wang*. Detecting fibroblast activation proteins in lymphoma using 68Ga-FAPI PET/CT,Journal of Nuclear Medicine,2022 Feb;49(3):1030-1040

Xie Qing, Lu Ming, Zhai Shizhen, Guo Rui, Du Changzhi, Zhu Hua, Li Nan, Yu Jiangyuan*, Yang Zhi*. Correlation between NEN bone metastasis performance and tumor proliferation: 112 cases of [68Ga]Ga-DOTA-TATE results analysis.,Neuroendocrinology.,2022;112(7):666-672.

Dan Li #, Feng Wang #, Jinquan Jiang, Xingguo Hou, Jin Ding, Zilei Wang, Yan Chen, Teli Liu, Zhi Yang*, Hua Zhu*. Construction of an iodine-labeled CS1001 antibody for targeting PD-L1 detection and comparison with low-molecular-peptide Micro-PET imaging.,Molecular Pharmaceutics,,2022 Nov 7, 19(11):4382-4389.

Guo Rui#, Yan Shi#, Wang Fei, Su Hua, Xie Qing, Zhao Wei, Yang Zhi*, Li Nan*, Yu Jiangyuan*. A novel diagnostic model for differentiation of lung metastasis from primary lung cancer in patients with colorectal cancer.,Front Oncol.,2022 Oct 24;12:1017618

Zhou Nina#, Zhang Aanan#, Su Hua, Zhao Wei, Li Nan*, Yang Zhi*. (18)F-FDG distribution pattern improves the diagnostic accuracy of single pulmonary solid nodule.,Front Oncol 2022, 12:983833.,2022, 12:983833.

Ren Yanan#,Liu Chen#,Liu Teli#,Duan Xiaojiang,Zhang Qian,Liu Jiayue,Wang Pei,Guo Qian,Yang Xing*,Du Peng*,Zhu Hua*,Yang Zhi*.Preclinical Evaluation and First in Human Study of Al18F Radiolabeled ODAP-Urea-based PSMA Targeting Ligand for PET Imaging of Prostate Cancer.,Frontiers in Oncology,,2022, 12:1030187.

Meng Tianyu, Meng Xiangxi*, Xu Xiaoxia, Li Xiaofan, Yang Zhi*, Li Nan*: Role of 18FDG PET/CT metabolic parameters in predicting hematological toxicity during chemoradiotherapy for locally advanced cervical cancer.,Frontiers in Oncology,2022, 12:9566252

Hou Xingguo#, Wang Feng#, Meng Xiangxi, Li Dan, Ding Jin, Chen Yan, Wang Zilei, Zhu Hua*, Yang Zhi*. Construction of a?124I-Labeled Specific Antibody for the Noninvasive Detection of Mesothelin-Overexpressing Tumors.,Mol Pharm.,2022 Oct 3;19(10):3623-3631.

Zhou Xin#, Wang Shuailiang#, Xu Xiaoxia#, Meng Xiangxi, Zhang Huiyuan, Zhang Annan, Song Yufei, Zhu H, Yang Zhi*, Li Nan*. Higher accuracy of [68?Ga]Ga-DOTA-FAPI-04 PET/CT comparing with 2-[18F]FDG PET/CT in clinical staging of NSCLC.,Eur J Nucl Med Mol Imaging.,2022 Jul;49(8):2983-2993.

Xue Qin,Xiangxi Meng,Yao Xiong,Xiaoyi Guo,Yanan Ren,Li Wen,Qian Zhang,Hua Zhu*,Zhi Yang*。Initial evaluation of 99mTc-labeled anti-carcinoembryonic antigen single-chain fragment variable for micro-single-photon emission computed tomography imaging in mice with colorectal cancer,Journal of labelled compounds & radiopharmaceuticals,https://doi.org/10.1002/jlcr.3960

Wang Shuailiang#, Liu Futiao#, Wang Pei, Wen Li, Wang Zilei, Guo Qian, Zhu Hua*, Yang Zhi*.?124I Radiolabeled Basiliximab for CD25-Targeted Immuno-PET Imaging of Activated T Cells.,Mol Pharm.,2022 Jul 4;19(7):2629-2637.

15.Meng Xiagnxi, Liu Hui, Li Hui, Wang Shujing, Sun Hongwei, Wang Feng, Ding Jin, He Liuchun, Chen Xin, Jin Lujia, Dong Yun, Zhu Hua*, Yang Zhi*. Evaluating the impact of different positron emitters on the performance of a clinical PET/MR system.,Med Phys.,2022 Apr;49(4):2642-2651.

Yanan Ren#, Teli Liu#, Chen Liu, Xiaoyi Guo, Feng Wang, Hua Zhu*, Zhi Yang*. An Albumin-Binding PSMA Ligand with Higher Tumor Accumulation for PET Imaging of Prostate Cancer..,Pharmaceuticals (Basel).,2022 Apr 22;15(5):513.

Ziren Kong #, Zhu Li#, Junyi Chen #, Wenbin Ma, Yu Wang*, Zhi Yang*, Zhibo Liu*, Larger 18F-fluoroboronotyrosine (FBY) active volume beyond MRI contrast enhancement in diffuse gliomas than in circumscribed brain tumors,,EJNMMI Res,,2022, 12(1):22

Ziren Kong#, Zhu Li#, Junyi Chen#, Sirui Liu, Delin Liu, Jiyuan Li, Nan Li, Wenbin Ma, Feng Feng, Yu Wang*, Zhi Yang*, Zhibo Liu*, Metabolic characteristics of [18F] fluoroboronotyrosine (FBY) PET in malignant brain tumors,,Nucl Med Biol,,2022, 106-107:80-87.

Li Dan#, Ding Jin#, Liu Teli, Wang Feng, Meng Xiangxi, Liu Song, Yang Zhi*, Zhu Hua*. SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice. Acta Pharmacol Sin. 2022 43:1749-1757 .,Acta Pharmacol Sin.,2022 43:1749-1757 .

Zhou Xin# Jiang Jinquan#, Yang Xue#, Liu Teli, Ding Jin, Nimmagadda S, Pomper MG, Zhu Hua*, Zhao Jun*, Yang Zhi*, Li Nan*. First-in-human evaluation of a PD-L1-binding peptide radiotracer in non-small cell lung cancer patients with PET.,J Nucl Med,2022 Apr;63(4):536-542

丁立新,王风,张岩,杨志*.北京市某医院新建PET/MR场所放射防护检测与评价,职业与健康,,2022,38(04):433-436+440.

Ziren Kong#, Zhu Li#, Junyi Chen#, Sirui Liu, Delin Liu, Jiyuan Li, Nan Li, Wenbin Ma, Feng Feng, Yu Wang*, Zhi Yang*, Zhibo Liu*, Metabolic characteristics of [18F] fluoroboronotyrosine (FBY) PET in malignant brain tumors,,Nucl Med Biol,,2022, 106-107:80-87.

潘永祥,王风,丁立新,等. 68Ga-奥曲肽PET/CT显像患者对周围人群产生的有效剂量的估算,国际放射医学核医学杂志,,2022,46(12):713-717.

Yu Jiangyuan#, Cao Fang#, Zhao Xinya, Xie Qing, Lu Ming, Li Jie, Yang Zhi*, Sun Yu*. Correlation and comparison of somatostatin receptor type 2 immunohistochemical scoring systems with 68Ga-DOTATATE PET/CT imaging in gastroenteropancreatic neuroendocrine neoplasms.,Neuroendocrinology,2022;112(4):358-369.

张在竹,周妮娜,朱华,杨志*.~(18)F-FDG PET/MRI在胰腺癌中的临床应用及新进展,国际放射医学核医学杂志,,2022,46(04):235-239.

Wang F, Guo R, Zhang Y, Yu B, Meng X, Kong H, Yang Y, Yang Z, Li N. Value of 18F-FDG PET/MRI in the Preoperative Assessment of Resectable Esophageal Squamous Cell Carcinoma: A Comparison With 18F-FDG PET/CT, MRI, and Contrast-Enhanced CT.,Front Oncol,2022 Feb 28;12:844702

Zaizhu Zhang#, Nina Zhou#, Xiaoyi Guo, Nan Li, Hua Zhu, Zhi Yang* Pretherapeutic Assessment of Pancreatic Cancer: Comparison of FDG PET/CT Plus Delayed PET/MR and Contrast-Enhanced CT/MR.,Front Oncol,2022;11:790462

Ding Wenxiang#,Yu Jiangyuan#,Zheng Chaojie; Fu Peng; Huang Qiu; Feng David Dagan; Yang Zhi*; Wahl Richard L*; Zhou Yun*. Machine learning-based noninvasive quantification of single-imaging session dual-tracer 18F-FDG and 68Ga-DOTATATE dynamic PET-CT in oncology.,IEEE Trans Med Imaging,2022 Feb;41(2):347-359.

李慧,杨志*.前列腺特异性膜抗原PET/MRI在前列腺癌中的应用现状与前景,协和医学杂志,2022,13(02):192-198.

Chen, Xuetao; Wei, Maomao; Wang, Shuailiang; Yang, Zhi; Wang, Xuejuan*. Characterizing Concomitant Follicular Lymphoma and Gastric Carcinoma Using 68Ga-FAPI-04 and 18F-FDG PET/CT.,Clinical nuclear medicine.,2022 Jan 1;47(1):81-82.

Xiaojiang Duan#, Zhen Cao#, Hua Zhu#, Chen Liu, Xiaojun Zhang, Jinming Zhang, Yanan Ren, Futao Liu, Xuekang Cai, Xiaoyi Guo, Zhen Xi, Martin G. Pomper, Zhi Yang*, Yan Fan*, Xing Yang*. 68Ga-Labeled ODAP-Urea-based PSMA Agents in Prostate Cancer: First-in-1 human Imaging of An Optimized Agent.,European Journal of Nuclear Medicine and Molecular Imaging,,2022 Feb;49(3):1030-1040

XXia L# Wen L#, Meng X, Zhou N, Guo X, Liu T, Xu X, Wang F, Zhu H*, Yang Z*. Application Analysis of 124I-PPMN for Enhanced Retention in Tumors of Prostate Cancer Xenograft Mice.,Int J Nanomedicine.,2021;16:7685-7695

Wen Li#, Xia lei#, Guo Xiaoyi, Huang Haifeng, Wang Feng, Yang Xianteng, Yang Zhi* and Zhu Hua*. Multimodal Imaging Technology Effectively Monitors HER2 Expression in Tumors Using Trastuzumab-Coupled Organic Nanoparticles in Patient-Derived Xenograft Mice Models.,Frontiers in Oncology.,2021 11:778728.

李囡, 周欣, 范洋, 张慧媛,丁立新,王茜*,杨志*. 北京市PET/CT影像报告质量控制及评估,中华核医学与分子影像杂志,,2021, 41(8) : 490-492.

朱华,杨志.肿瘤新型放射性药物的研发与应用,中华核医学与分子影像杂志,2021,41(10):577-579

Rui Guo, Xiangxi Meng, Fei Wang, Jiangyuan Yu, Qing Xie, Wei Zhao, Lin Zhu,Hank F. Kung,Zhi Yang*, Nan Li*.68Ga-P15-041, A Novel Bone Imaging Agent for Diagnosis of Bone Metastases.,Frontiers in Oncology.,November 2021. Volume 11

丁立新, 王风, 杨志*. 北京市核医学2019年基本情况调查分析,国际放射医学核医学杂志,2021, 45(6): 370-375.

Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu*, Zhi Yang*, Zhaofei Liu*.Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy.,J Nanobiotechnology.,2021 Jun 10;19(1):175

Nina Zhou#, Xiangxi Meng#, Yan Zhang, Boqi Yu, Jianmin Yuan, Jiangyuan Yu, Hua Zhu*, Zhi Yang*. Diagnostic value of delayed PET/MR in liver metastasis in comparison with PET/CT.,Frontiers in Oncology,2021 Aug 30;11:717687

Wang Shuailiang, Zhou Xin, Xu Xiaoxia, Ding Jin, Liu Song, Hou Xingguo, Li Nan, Zhu Hua*, Yang Zhi*. Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging.,Eur J Nucl Med Mol Imaging.,2021 Dec;48(13):4259-4271.

Li Hui,Liu Yanqing,Zang Jie et al. Inferior Vena Cava Tumor Thrombus From Thyroid Cancer Detected by 68Ga-PSMA-617 PET/CT.,Clin Nucl Med.,2021, 46: 264-265.

Li Hui, Meng Xiangxi, Guan Xiangping, Zhou Nina, Liu Hui, Zhang Yan, Yu Boqi, Zhu Hua, Li Nan, Yang Zhi*. Clinical Evaluation of MR-Gated RespiratoryMotion Correction in Simultaneous PET/MRI.,Clin Nucl Med.,2021; 46: 297-302.

Shujing Wang#, Hua Zhu#*, Jin Ding, Feng Wang, Lixin Ding, Yan Zhang, Nan Li, Sheng Yao, Xinan Sheng*, Zhi Yang*. Positron Emission Tomography Imaging of Programmed Death 1 Expression in Cancer Patients Using Iodine-124 Labeled Toripalimab: A Pilot Clinical Translation Study.,Clinical Nuclear Medicine,,2021, 46(5),382-388.

Xiaoxia Xu, Hua Zhu, Hank F. Kung, Nan Li*, Zhi Yang*.Benign Adrenal Nodule Mimicking Lymphoma were Differentially Diagnosed by 18F-FDG and 18F-FGln PET/CT.,Clinical Nuclear Medicine,,2021;46:474-476

Zhu Li#, Ziren Kong#, Junyi Chen#, Jiyuan Li, Nan Li, Zhi Yang*, Yu Wang*, Zhibo Liu*. 18F-Boramino acid PET/CT in healthy volunteers and glioma patients.,European Journal of Nuclear Medicine and Molecular Imaging,2021, DOI:10.1007/s00259-021-05212-7.

Jinquan Jiang, Dan Li, Teli Liu, Lei Xia, Xiaoyi Guo, Xiangxi Meng, Feng Wang, Zhi Yang, Hua Zhu*. Noninvasive evaluation of PD-L1 expression using Copper 64 labeled peptide by Micro-PET imaging.,Bioorganic & Medicinal Chemistry Letters.,2021, 40,127901.

Shuailiang Wang#, Xin Zhou#, Xiaoxia Xu#, Jin Ding, Teli Liu, Jinquan Jiang, Nan Li*, Hua Zhu*, Zhi Yang*. Dynamic PET/CT imaging of 68Ga-FAPI-04 in Chinese subjects,Frontiers in Oncology,,2021, 11, 651005.

Qing Xie, Teli Liu, Jing Ding, Nina Zhou, Xiangxi Meng, Hua Zhu, Nan Li, Jiangyuan Yu*, Zhi Yang*.Synthesis, preclinical evaluation, and a pilot clinical imaging study of [18F]AlF-NOTA-JR11 for neuroendocrine neoplasms compared with [68Ga]Ga-DOTA-TATE.,European Journal of Nuclear Medicine and Molecular Imaging,2021, DOI: 10.1007/s00259-021-05249-8.

Lei Xia, Xiangxi Meng, Li Wen, Nina Zhou, Teli Liu, Xiaoxia Xu, Feng Wang, Zhen Cheng, Zhi Yang*, Hua Zhu*. A Highly Specific Multiple Enhancement Theranostic Nanoprobe for PET/MRI/PAI Image-Guided Radioisotope Combined Photothermal Therapy in Prostate Cancer.,Small,2021, DOI: 10.1002/smll.202100378.

Liu Teli#, Liu Chen#, Zhang Zhongyi#, Zhang Ning, Guo Xiaoyi, Xia Lei, Jiang Jinquan, Xie Qing, Yan K, Rowe SP, Zhu Hua, Yang Zhi. 64Cu-PSMA-BCH: a new radiotracer for delayed PET imaging of prostate cancer. Eur J Nucl Med Mol Imaging.,Eur J Nucl Med Mol Imaging,2021 Jun 25. doi: 10.1007/s00259-021-05426-9. Epub ahead of print. PMID: 34170361

Zhu Hua*#; Zhang Hanwen#; Zhou Nina#; Ding Jin; Jiang Jinquan; Liu Teli; Liu Ziyu; Wang Feng; Zhang Qian; Zhang Zhuochen; Yan Shi; Li Lei; Benabdallah Nadia; Jin Hongjun; Liu Zhaofei; Cai Lisheng; Thorek Daniel L. J*.; Yang Xing*; Yang Zhi*。 Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2. Adv Sci (Weinh).,ADVANCED SCIENCE,2021 Jun 26:e2100965. doi: 10.1002/advs.202100965. Epub ahead of print. PMID: 34174177. (SCI IF 16.806 Q1 )

Gao Yujie, Yang Zhi, Yu Jiangyuan, Li Nan, Wang Xuejuan, Zhou Nina. Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review.,Nucl Med Commun.,2021 Jul 1;42(7):800-810.

周欣, 张慧媛, 王淑静, 朱华, 杨志, 李囡*. 非小细胞肺癌靶向PET显像的临床研究进展.,[J]中华临床医师杂志(电子版),2021;15(02):123-128.

蒋金泉, 李丹, 刘特立, 徐晓霞, 夏雷, 郭晓轶, 朱华*, 杨志. 肿瘤免疫治疗PD-L1靶向新型PET分子探针68Ga-WL12研制、质控及初步生物学研究。,中国医学影像技术.,2021, 37(1), 79-83.

高玉杰,周妮娜*,李囡,范洋,杨志.~(11)C-MET PET/CT诊断脑胶质瘤术后复发残留的初步研究,实用肿瘤杂志,2021,36(02):154-159.

王帅亮,朱华,杨志*。T细胞核医学分子成像策略在CAR-T免疫治疗中的应用.,中华核医学与分子影像杂志.,2021, 41(3)175-179.

杨敏福,范岩,李文婵,牛娜,孙晓昕,张卫方,张晓丽,王茜,杨志.核素心肌灌注显像报告书写规范,中国医学影像学杂志,2021,29(03):193-195.

李詝,李囡,刘志博,杨志.~(18)F-硼氨酸细胞摄取机制研究,首都医科大学学报,2021,42(01):15-20.

王茜,李囡,霍力,杨吉刚,艾林,李河北,富丽萍,张建华,杨志.核医学~(18)F-FDG PET/CT报告书写规范,[J].中国医学影像学杂志,,2021,29(01):1-3.

李囡,王茜,付占立,景红丽,郑容,于江媛,杨芳,李艳,童冠圣,杨志.核医学单光子显像报告书写规范,中国医学影像学杂志,,2021,29(02):97-99.

王帅亮,朱华,杨志*。T细胞核医学分子成像策略在CAR-T免疫治疗中的应用.,中华核医学与分子影像杂志.,2021, 41(3)175-179.

谢卿,李慧,刘特立,翟士桢,王风,王丽,杨建华(译),朱华,杨志(审校)。美国、欧洲联盟和加拿大能否在放射性药物的临床首次应用规范方面达成共识?,中华核医学与分子影像杂志.,2021, 41(3)185-192

Teli Liu#, Chen Liu#, Yanan Ren, Xiaoyi Guo, Jinquan Jiang, Qing Xie, Lei Xia, Feng Wang, Hua Zhu*, Zhi Yang*. Development of an albumin-based PSMA probe with prolonged half-life.,Frontiers in Molecular Biosciences.,2020, 7. 585024. (SCI IF 5.246Q2 ) PMID: 33392253 PMCID: PMC7773938 DOI: 10.3389/fmolb.2020.585024

王风, 朱华, 李立强, 郭晓轶, 刘特立,杨志*. 新型固体靶核素~(89)Zr的制备、标记和临床前应用研究进展,同位素,2020, 33(02): 117-123.

北京市核医学质量控制和改进中心北京市医师协会核医学医师专科分会. 新冠肺炎非定点救治医院核医学影像检查中的防控措施,中华放射医学与防护杂志,2020, 40(3): 168-172.

Wang Guochang#., Jin Xiao#., Zhu Hua., Wang Shuailiang., Ding Jin., Zhang Yan., Yang Zhi*.,Wang Xuejuan*. (68)Ga-NOTA-FAPI-04 PET/CT in a patient with primary gastric diffuse large B cell lymphoma: comparisons with [(18)F] FDG PET/CT,Eur J Nucl Med Mol Imaging,2020.

Zhou Nina#, Liu Chang#, Guo Xiaoyi#, Xu Yuping, Gong Jifang, Qi Changsong, Zhang Xiaotian, Yang Min*, Zhu Hua*, Shen Lin*,Yang Zhi*. Impact of (68)Ga-NOTA-MAL-MZHER2 PET imaging in advanced gastric cancer patients and therapeutic response monitoring,Eur J Nucl Med Mol Imaging,2020, Jun(20).

陈曙光, 胡鹏程, 樊卫, 莫逸, 王峰, 卢洁, 高永举, 杨志, 赵军, 杜雪梅, 张政,石洪成*. PET/MR全身显像工作流及协议规划专家共识,中国临床医学,2020, 27(04): 713-721.

Xiaojiang Duan#, Futao Liu#, Hongmok Kwon, Youngjoo Byun, Il Minn, Xuekang Cai, Jingming Zhang, Martin G. Pomper, Zhi Yang*, Zhen Xi*, Xing Yang*. (S)-3-(Carboxyformamido)-2-(3-(carboxymethyl)ureido)propanoic Acid as a Novel PSMA Targeting Scaffold for Prostate Cancer Imaging.,Journal of Medicinal Chemistry,.,2020, 63(7):3563-3576

邓虞娇,朱华,杨志,彭志平,贾建华.中枢神经系统临床用PET显像剂的研究进展262.,同位素,2020,33(04):250-262.

Xiaoyi Guo#, Nina Zhou#, Zuhua Chen#, Teli Liu, Xiaoxia Xu, Xia Lei, Lin Shen, Jing Gao, Zhi Yang*, Hua Zhu1,*. Construction of 124I-trastuzumab for Noninvasive PET Imaging of HER2 Expression: From Patient-derived Xenograft Models to Gastric Cancer Patients.,Gastric Cancer. 2020.,2020: 1-13.

Haifeng Huang#, Hua Zhu#, Quan Xie, Xiao-Bin Tian, Xian-Teng Yang, Fan Feng, Qi-Yu Jiang, Xi-Nan Sheng?, Zhi Yang*. Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice.,Acta Pharmaceutica Sinica B.,2020,

Nina Zhou#, Xiaoyi Guo#, Min Yang, Hua Zhu*, Zhi Yang*.68Ga-ZHER2 PET/CT Reveals HER2-positive Metastatic Gastric Cancer with Better Image Quality than 18F-FDG.,Clinical Nuclear Medicine,,2020, 45(2): e101-e102.

孟天宇, 于江媛, 李囡,杨志*. PET/CT显像在化疗相关心肌损伤中的应用,中华核医学与分子影像杂志,2020, 40(03): 179-182.

Teli Liu?, Chen Liu?, Yanan Ren, Xiaoyi Guo, Jinquan Jiang, Qing Xie, Lei Xia, Feng Wang, Hua Zhu*, Zhi Yang*. Development of an albumin-based PSMA probe with prolonged half-life.,Frontiers in Molecular Biosciences.,2020, 7. 585024.

王风, 郭晓轶, 刘特立, 丁立新,夏雷,丁缙,蒋金泉,朱华,杨志. 固体靶PET核素89Zr的制备、质量控制和抗体标记,中华核医学与分子影像杂志. DOI: 10.3760/cma.j.cn321828-20191018-00226,,2020,40 (05): 294-297

马圆,王风,韩勇,张凤,梁志刚,黄健,杨志*,郭秀花*.基于深度信念网络检测PET/CT图像肺结节良恶性.,中国医学影像技术,,2020,36(1):77~80

Yan-Qing Liu, Zhi Yang, Yan-Song Lin*. Reactions to COVID-19: actions of nuclear medicine healthcare personnel in China.,Eur J Nucl Med Mol Imaging.,2020, DOI 10.1007/s00259-020-04857-0.

兰晓莉,高再荣,杨志,李思进*,李亚明*. 2019新型冠状病毒感染疫情期间核医学诊疗安全防控专家共识(第一版).,中华核医学与分子影像杂志.,2020, 40(3), 129-134.

王风,朱华,李立强,郭晓轶,刘特立,杨志*. 新型固体靶核素Zr-89的制备、标记和临床前应用研究进展,同位素.,2020, 33(2): 117-123

Qian Yu#, Lixin Wang#, Jin Ding, Zhi Yang, Chengchao Shou, Chuanke Zhao*, Hua Zhu*. Evaluation of 111In-DOTA-F56 peptide targeting VEGFR1 for potential non-invasive Gastric Cancer xenografted tumor mice Micro-SPECT imaging.,Bioorganic & Medicinal Chemistry Letters.,2020, 30, 127248

Xudong Wang#, Feng Wang#, Jintao Han, Zhi Yang, Hua Zhu,* Gen Yang*. Construction and Preclinical Evaluation of a 124/131I?Labeled Radiotracer for the Detection of Mesothelin-Overexpressing Cancer.,Molecular Pharmaceutics.,2020 Jun 1;17(6):1875-1883.Epub 2020 May 9

Song Jinling, Li Zhongwu, Chen Puyun, Zhou Nina, Zhang Yan, Yang Zhi,Wang Xuejuan. The correlation between molecular pathological profiles and metabolic parameters of (18)F-FDG PET/CT in patients with gastroesophageal junction cancer,[Abdominal radiology (New York),2020, 45(2): 312-321.

Xianteng Yang#, Hua Zhu#, Xing Yang, Chaoyong Deng, Nan Li, Haifeng Huang, Teli Liu, Xiaoyi Guo, Xiaoxia Xu, Lei xia, Xiaobin Tian*, Zhi Yang*. Targeting CAIX with [64Cu]XYIMSR-06 small molecular radio-tracer enables non-invasive PET imaging of malignant glioma in U87 MG tumor cell xenograft mice.,Mol. Pharmaceutics,2019, 16, 1532-1540.

Fei Liu, Xiaoyi Guo, Teli Liu, Xiaoxia Xu, Nan Li, Chiyi Xiong, Chun Li, Hua Zhu,* Zhi Yang*. 64Cu-Labeled pan-SSTRs Targeted Precursor PA1 for Micro-Positron Emission Tomography Imaging.,ACS Medicinal Chemistry Letters.,2020. DOI: 10.1021/acsmedchemlett.9b00544. (Q2, SCI 3.74).

Xun Feng, Yanpu Wang, Dehua Lu, Xiaoxia Xu, Xin Zhou, Huiyuan Zhang, Ting Zhang, Hua Zhu, Zhi Yang, Fan Wang, Nan Li*, Zhaofei Liu*. Clinical Translation of a 68Ga-labeled Integrin αvβ6-targeting Cyclic Radiotracer for PET Imaging of Pancreatic Cancer,Journal of Nuclear Medicine,,2020. doi:10.2967/jnumed.119.237347

Chen Liu#, Teli Liu#, Zhongyi Zhang#, Ning Zhang, Peng Du, Yong Yang, Yiqiang Liu, Wei Yu, Nan Li, Michael A Gorin, Steven P. Rowe*, Hua Zhu*, Kun Yan*, Zhi Yang*. PSMA PET/CT and standard plus PET/CT-Ultrasound fusion targeted prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsies.,Journal of Nuclear Medicine,2020-Feb-07 (Epub 2020 Feb 07)

Jinquan Jiang#, Meixin Zhang#, Guanghui Li, Teli Liu, Zhaofei Liu, Yakun Wan, Hua Zhu*, Zhi Yang*. Evaluation of 64Cu radiolabeled anti-hPD-L1 Nb6 for positron emission tomography imaging in lung cancer tumor mice model.,Bioorganic & Medicinal Chemistry Letters. 2020,2020, 30(4), 126915. (Q2, SCI 2.442)

Xiaoxia Xu#, Hua Zhu#, Fei Liu, Yan Zhang, Jianhua Yang, Lifang Zhang, Qing Xie, Lin Zhu, Nan Li*, Hank F. Kung*, Zhi Yang*. Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.,European Journal of Nuclear Medicine and Molecular Imaging,,PMID: 32166510 DOI: 10.1007/s00259-019-04543-w

Hua Zhu#, Teli Liu#, Changhao Liu, Jing Wang, Hong Zhang, Bin Dong, Jing Shen, Chuanke Zhao, Zhenfu Li, Zhen Cheng*, Zhi Yang*. Evaluation of a novel monoclonal antibody mAb109 by immuno-PET/fluorescent imaging for noninvasive lung adenocarcinoma diagnosis.,Acta Pharmacologica Sinica.,2020. 41, 101-109. (SCI IF 4.0 Q1 )

王淑静,徐晓霞,周欣,刘特立,李囡,朱华*,杨志*. 肿瘤免疫治疗PD-1/PD-L1靶向核素分子探针的研究进展.,肿瘤防治研究.,2020, 47(01): 70-76.

王风,王磊,李囡,杨志,基于三维卷积神经网络深度学习的肺结节良恶性的鉴别诊断,,中国医学影像学杂志,2019,27(10):779-782+787.

黄海峰, 朱华, 杨先腾, 郭晓轶, 李姗姗, 谢泉, 田晓斌*, 杨志*. 恶性骨肿瘤中程序性死亡蛋白1及其配体的临床研究进展.,中华肿瘤杂志,,2019, 41(6), 410-414.

周妮娜,于江媛,朱华,赵伟,杨志.腹部纤维母细胞/肌纤维母细胞性肿瘤的PET/CT影像学特点及其应用价值.,肿瘤防治研究.,2019,46(3):243-247.

刘特立,刘辰,夏雷,郭晓轶,蒋金泉,朱华,李囡,王铁*,杨志*.PSMA分子探针Al18F-PSMA-BCH的制备及其临床应用.,中华核医学与分子影像杂志.,2019,39(12):743-747

刘辰,刘特立,杨志,张宁,杜鹏,杨勇,刘毅强,王静,严昆,杨兴,朱华,李囡*. 68Ga-PSMA-617 PET/CT对高危前列腺癌的预测价值.,中华核医学与分子影像杂志,2019,39(2):77-80.

蒋金泉, 刘特立, 夏雷, 朱华*, 杨志. 小分子肽免疫检查点抑制剂PET探针引导肿瘤免疫治疗新进展.,国际肿瘤学杂志,2019, 46(8), 449-452.

周妮娜,朱华,杨志.靶向HER2阳性肿瘤的PET/CT分子显像临床研究进展,肿瘤防治研究.,2019,46(04):376-381.

朱华, 刘特立, 王风, 蒋金泉, 韩雪迪, 杨志*. 64Cu标记DKFZ-PSMA-617探针的制备、质控及体内分布的研究,[J]. 同位素,,2019, 32(6), 382-387.

张美欣, 刘特立, 郭晓轶, 徐晓霞, 朱华*, 杨志.单域抗体在肿瘤分子影像学中的研究进展,肿瘤防治研究,2019, 46(03): 262-265.

郭晓轶,周妮娜,刘特立,徐晓霞,夏雷,朱华*,杨志*. 分子影像引导HER2阳性肿瘤诊疗新进展,肿瘤防治研究,2019. 46(6), 551-555.

Chen Liu#, Teli Liu#, Jingjing Zhang, Richard P. Baum, Zhi Yang*. Excellent Response to Lu-177-DOTATATE PRRT in a Patient with Progressive Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Neuroendocrine Differentiation After Lu-177-PSMA Therapy.,Clinical Nuclear Medicine,2019 44: 876-878. (SCI IF 6.5 Q1 )

Lei Xia, Xiaoyi Guo, Teli Liu, Xiaoxia Xu, Jinquan Jiang, Feng Wang, Zhen Cheng, Hua Zhu*, Zhi Yang*. Multimodality Imaging of Naturally Active Melanin Nanoparticles Targeting Somatostatin Receptor Subtype 2 in Human Small-Cell Lung Cancer.,Nanoscale. 2019, 11, 14400-14409. (Q1, SCI 7.23),2019, 11, 14400-14409.

43. Xiaoyi Guo?, Hua Zhu?, Teli Liu, Xiaoxia Xu, Yan Kong, Sheng Yao, Xinan Sheng*, Zhi Yang*. Development of 99mTc-conjugated JS001 antibody for in vivo mapping of PD-1 distribution in murine.,Bioorganic & Medicinal Chemistry Letters. 2019. 25(16), 2178-2181 . (Q2, SCI 2.442),2019. 25(16), 2178-2181 .

Xianteng Yang#, Fan Wang#, Hua Zhu; Zhi Yang*, TaiWei Chu*. Synthesis and bioevaluation of novel 18FDG-conjugated 2-nitroimidazole derivatives for tumor- hypoxia imaging.,Mol. Pharmaceutics,2019, 16, 2118-2128.

Hua Zhu#, Teli Liu#, Changhao Liu, Jing Wang, Hong Zhang, Bin Dong, Jing Shen, Chuanke Zhao, Zhenfu Li, Zhen Cheng*, Zhi Yang*. Evaluation of a novel monoclonal antibody mAb109 by immuno-PET/fluorescent imaging or noninvasive lung adenocarcinoma diagnosis. Acta Pharmacologica Sinica.,Acta Pharmacologica Sinica,2020;41(1):101–109.

仲外医学奖教金, 仲外医学奖教金, 第1完成人, 北京大学医学部, 2021.9

Al18F标记的PSMA靶向抑制剂及其制备方法与应用, 第五届产学研合作优秀项目,一等奖, 第1完成人, 北京大学, 2021.5

10.“HER2靶向新型分子探针AL18F-HER2-BCH的临床应用与转化”北大医学首届创新转化大赛,生物医学组一等奖, 一等奖, 第1完成人, 北大医学, 2022.9

人表皮生长因子受体-2(HER2)靶向PET分子探针的研发应用, 首都转化医学创新大赛,三等奖及最佳创意奖, 第1完成人, 北京市卫生健康委, 2021.12

“新一代前列腺癌特异性靶向PMSA诊疗一体化探针的研究与临床转化”, 北京大学肿瘤医院第一届科技创新转化大赛, 第1完成人, 北京大学肿瘤医院, 2020.12

2020年度中华医学会核医学分会突出贡献奖, 突出贡献奖, 第1完成人, 中华医学会核医学分会, 2020.9

正电子发射断层(PET)显像的技术创新及转化应用, 中华医学科技奖 二等奖, 第4完成人, 中华医学会, 2019.12

一种前列腺特异性膜抗原靶向抑制剂及其应用和探针, 发明专利, 第1完成人, 国家专利局, 中国, 2022.9

一种CD25靶向多肽、分子探针及应用, 发明专利, 第1完成人, 国家专利局, 中国, 2022.9

三模态前列腺癌靶向纳米粒子显像剂及其制备方法, 发明专利, 第1完成人, 国家专利局, 中国, 2022.4

放射性核素标记生长抑素受体拮抗剂及其制备方法和应用, 发明专利, 第1完成人, 国家专利局, 中国, 2022.6

一种ACE受体靶向核素多肽探针及其制备方法和应用, 发明专利, 第2完成人, 国家专利局, 中国, 2022.7

18F-(2S ,4R)-4-氟-L-谷胺酰胺的自动化生产设备, 发明专利, 第1完成人, 中华人民共和国专利局, 中国, 2020.3

放射性核素标记的过氧化氢酶及其应用, 发明专利, 第1完成人, 国家专利局, 中国, 2023.2

一种用于整合素αvβ6 靶向的环状多肽放射性药物及其制备方法, 发明专利, 第4完成人, 中华人民共和国专利局, 中国, 2019.10

HER2亲和体和诊疗核素标记物及其制备方法与应用, 发明专利, 第1完成人, 中华人民共和国专利局, 中国, 2021.6

防阻塞吸引管, 实用新型, 第2完成人, 中华人民共和国专利局, 中国, 2021.5

一种小白鼠实验用解剖固定装置, 实用新型, 第3完成人, 国家专利局, 中国, 2022.11

一种前列腺特异性膜抗原靶向抑制剂及应用和探针, 发明专利, 第2完成人, 中华人民共和国专利局, 中国, 2020.8

Al18F标记的PSMA靶向抑制剂及其制备方法与应用, 发明专利, 第1完成人, 中华人民共和国专利局, 中国, 2021.4

登峰人才计划:核医学(杨志), 课题负责人, 2020.1.1~2023.12.31, 登峰人才计划

CD25靶向探针的构建及其在CAR-T治疗显像中的应用, 课题负责人, 2022.1.1~2025.12.31, 国家自然科学基金

研究制备脑疾病早期诊断特异性PET示踪剂及其临床应用, 课题负责人, 2022.11.1~2023.10.31, 科技部国家重点研发计划

原创靶向免疫放射性药物研制转化和医用级Zr-89核素制备, 课题负责人, 2023.1.2~2025.12.31, 国家科工局

前列腺癌靶向PET探针的开发及临床转化研究, 课题负责人, 2022.1.1~2022.11.30, 北京大学肿瘤医院

肿瘤核医学精准诊疗一体化研究论坛, 课题负责人, 2020.5.1~2020.12.31, 北京市自然科学基金

肿瘤核医学专业, 课题负责人, 2018.1.4~2020.12.31, 扬帆计划-重点医学专业

A2δ1亚基阳性特异性PET探针的构建及在肝癌干细胞诊疗的研究, 课题负责人, 2019.1.1~2022.12.31, 国家自然科学基金

基于复轮廓波变换提取多模态影像纹理及相关因素构建深度信念网络肺癌早期诊断模型, 子课题负责人, 2018.9.1~2020.9.30, 国家自然科学基金

18F-氟代谷氨酰胺探针的肿瘤氨基酸代谢显像及其与 Myc 基因调控相关机制的研究, 课题负责人, 2017.1.7~2020.12.31, 2017年 北京市自然科学基金 重点项目 7171002

前列腺癌PSMA靶向PET探针的开发及临床转化研究, 课题负责人, 2020.1.1~2020.12.31, 北京大学肿瘤医院

89Zr-CTB006单克隆抗体的制备、质控研究, 课题负责人, 2019.3.1~2020.12.31, 北京先通生物医药技术有限公司

PET分子探针在淀粉样脑血管病诊断中的临床研究, 课题负责人, 2019.1.1~2020.12.31, 首都医科大学附属北京天坛医院

核素/红外双模特意SLN探针的构建, 课题负责人, 2018.1.4~2019.12.31, 论文奖励

靶向生长抑素受体各亚型的68Ga/177Lu-PA探针的构建及其在肿瘤个体化诊疗中的研究, 课题负责人, 2016.1.1~2019.12.31, 2015年 国家自然科学基金 编号 NO 881571705

研究生招生计划
招生年度 招生专业 学位级别 学位类型 研究方向 选拔方式 操作
2024 影像医学与核医学 博士 科学学位 肿瘤靶向放射性药物研究及转化 申请考核制
2024 影像医学与核医学 硕士 科学学位 肿瘤靶向放射性药物研究及转化 全国统考

社会任职

  • 中国核学会常务理事副秘书长
  • 国家药品管理局放射性药品研究与评价重点实验室主任
  • 北京精准医学会放射性药物分会主任委员
  • 中国整合医学联盟医学影像分会副主任委员
  • 中国医学康复会医学影像分会副主任委员

学习、工作经历

  • 2006.9.1~2009.6.30,中国原子能科学研究院,放射性同位素应用专业,工学博士
  • 2005.10.1~2007.11.30,美国德州大学,MD Anderson肿瘤中实验影像诊断系,访问学者
  • 2000.9.1~2003.7.31,北京大学,技术物理系核技术应用专业 ,硕士
  • 1992.12.31~2020.1.13,北京市肿瘤防治研究所(北京肿瘤医院),核医学科,研究实习员、助理研究员副研究员、研究员、副主任、主任
  • 1989.7.31~1992.12.31,1989/07-1992/12,中国原子能科学研究院同位素所,研究实习员