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导师基本信息

  • 姓名:张维敏
  • 性别:
  • 民族:汉族
  • 科室:分子肿瘤学研究室
  • 职称:副研究员
  • 专业:肿瘤学
  • E-MAIL: wmzhang411@163.com

学术论文 | 奖励表彰 | 研究方向 | 专利 | 科研项目

Xuesong Liu #, Mengzhu Lv #, Weimin Zhang*, Qimin Zhan*. Dysregulation of cholesterol metabolism in cancer progression,Oncogene,42(45):3289-3302

Mengzhu Lv #, Ying Gong #, Xuesong Liu #, Yan Wang, Qingnan Wu, Jie Chen, Qingjie Min, Dongyu Zhao, Xianfeng Li, Dongshao Chen, Di Yang, Danna Yeerken, Rui Liu, Jinting Li, Weimin Zhang*, Qimin Zhan*, CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties,SIGNAL TRANSDUCTION AND TARGETED THERAPY,8(1):302

Xiao W, Yeerken D, Li J, Li Z, Jiang L, Li D, Fu M, Ma L, Song Y, Zhang W*, Zhan Q*. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.,Signal Transduct Target Ther.,2021 Apr 16;6(1):152.

Zhang H#, Wang Y#, Zhang W#, Wu Q, Fan J, Zhan Q. BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma.,Cancer Commun (Lond).,41(3):240-257.

Dezuo Dong#, Weimin Zhang#, Wenchang Xiao, Qingnan Wu, Yiren Cao, Xiaohan Gao, Lijie Huang, Yan Wang, Jie Chen, Weihu Wang, Qimin Zhan. A GRN Autocrine-dependent FAM135B/AKT/mTOR Feedforward Loop Promotes Esophageal Squamous Cell Carcinoma Progression.,Cancer Research,2021 Feb 15;81(4):910-922.

Rui Liu, Ruoxi Hong, Yan Wang, Ying Gong, Danna Yeerken, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang*, Qimin Zhan*. Defect of SLC38A3 promotes epithelial mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma.,Chinese Journal of Cancer Research.,32(5):547-563.

Danna Yeerken, Ruoxi Hong, Yan Wang, Ying Gong, Rui Liu, Di Yang, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang*, Qimin Zhan*, PFKP is transcriptionally repressed by BRCA1/ZBRK1 and predicts prognosis in breast cancer,PLoS One,2020 May 29;15(5):e0233750.

Q.N. Wu#, W.M. Zhang#, L.Y. Xue, Y. Wang, M. Fu, L.Y. Ma, Y.M. Song, Q.M. Zhan, APC/C-CDH1-Regulated IDH3 beta Coordinates with the Cell Cycle to Promote Cell Proliferation,Cancer Research,79 (2019) 3281-3293

Ning Ding # , Yikun Cheng # , Huijuan Liu, Yueguang Wu, Yongjia Weng, Heyang Cui, Chen Cheng, Weimin Zhang*, Yongping Cui*. Fusobacterium nucleatum Infection Induces Malignant Proliferation of Esophageal Squamous Cell Carcinoma Cell by Putrescine Production.,Microbiol Spectr.,e0275922

Heyang Cui #, Yong Zhou #, Fang Wang #, Caixia Cheng #, Weimin Zhang #, Ruifang Sun #, Ling Zhang #, Yanghui Bi, Min Guo, Yan Zhou, Xinhui Wang, Jiaxin Ren, Ruibing Bai, Ning Ding, Chen Cheng, Longlong Wang, Xuehan Zhuang, Mingwei Gao, Yongjia Weng, Yueguang Wu, Huijuan Liu, Shuaicheng Li, Shubin Wang, Xiaolong Cheng, Yongping Cui*, Zhihua Liu*, Qimin Zhan*, Characterization of somatic structural variations in 528 chinese individuals with esophageal squamous cell carcinoma,Natue Communications,13(1):6296

Xuesong Liu#, Ruoxi Hong#, Peina Du#, Di Yang#, Meibo He, Qingnan Wu, Lin Li, Yan Wang, Jie Chen, Qingjie Min, Jinting Li, Weimin Zhang*, Qimin Zhan*, The metabolic genomic atlas reveals potential drivers and clinically relevant insights into the etiology of esophageal squamous cell carcinoma,THERANOSTICS,12(14):6160-6178

Chen Cheng, Heyang Cui, Huijuan Liu, Yueguang Wu, Ning Ding, Yongjia Weng, Weimin Zhang*, Yongping Cui*, Role of epidermal growth factor receptor-specific car-t cells in the suppression of esophageal squamous cell carcinoma,CANCERS,14(24):6021

Kai Zhang#, Qingnan Wu#, Wenzhong Liu, Yan Wang, Lianmei Zhao, Jie Chen, Haoyu Liu, Siqi Liu, Jinting Li, Weimin Zhang*, Qimin Zhan*, Fam135b sustains the reservoir of tip60-atm assembly to promote dna damage response,CLIN TRANSL MED,12(8):e945.

Qingnan Wu#, Weimin Zhang#, Yan Wang, Qingjie Min, Hongyue Zhang, Dezuo Dong, Qimin Zhan, Mage-c3 promotes cancer metastasis by inducing epithelial-mesenchymal transition and immunosuppression in esophageal squamous cell carcinoma,CANCER COMMUN,41(12):1354-1372

北京市科技新星, 北京市科技新星, 第1完成人, 北京市科创委, 2019.11

第九批北京市优秀青年人才, 第九批北京市优秀青年人才, 第1完成人, 北京市委组织部, 2021.5

常山酮衍生物及其药物组合物和用途, 发明专利, 第3完成人, 北京肿瘤医院, 中国, 2021.12

《肿瘤发生发展多维组学时空网络研究与表型组解析》课题2《肿瘤代谢和核酸、蛋白互作与修饰调控网络》, 参加者, 2022.11.1~2027.10.31, 国家重点研发计划重点专项

DH3β与中心体蛋白相互作用的分子机理及其作为肿瘤潜在治疗靶点的研究, 课题负责人, 2019.11.1~2023.8.1, 北京市科技新星项目

肿瘤细胞内稳态与微生态协同演化的机制研究, 子课题负责人, 2020.11.1~2024.10.31, 深圳湾实验室重大项目

mTOR/FAM135B/ATG16L1信号通路抑制自噬发生在食管鳞癌发生发展中的作用及机制研究, 课题负责人, 2019.1.1~2021.12.31, 国家自然基金

Nlp调控COPII囊泡转运的机制及其在肿瘤发生发展中的作用, 课题负责人, 2022.1.1~2025.12.31, 国家自然基金面上项目

联合靶向天冬氨酸代谢和免疫检查点提高乳腺癌治疗疗效的机制研究, 课题负责人, 2019.9.1~2021.12.31, 北京市医管中心“青苗计划”

社会任职

  • The Youth Editor of The Innovation
  • 广东省病理生理学会第一届肿瘤专业委员会委员
  • The Science Editor of Military Medical Research
  • 北京肿瘤防治研究学会肿瘤微环境分委会委员
  • 中国老年学和老年医学会老年肿瘤分会转化医学专家委员会

学习、工作经历

  • 2019.8.1~,北京大学肿瘤医院,副研究员
  • 2019.4.1~2019.7.31,北京大学肿瘤医院,助理研究员
  • 2017.4.1~2019.4.1,北京大学肿瘤医院,博士后
  • 2015.7.31~2017.3.31,广州赛莱拉干细胞科技股份有限公司,技术中心副总监
  • 2010.9.1~2015.7.1,北京协和医学院,理学博士(直博)