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导师基本信息

  • 姓名:陆哲明
  • 性别:
  • 民族:汉族
  • 科室:生化与分子生物学研究室
  • 职称:研究员,教授
  • 专业:肿瘤学
  • E-MAIL: Luzheming@bjmu.edu.cn

学术论文 | 综述述评 | 研究方向 | 专利 | 科研项目 | 招生计划

Li S, Zhang C, Shen L, Teng X, Xiao Y, Yu B*, Lu Z*. TCR extracellular domain genetically linked to CD28, 2B4/41BB and DAP10/CD3ζ -engineered NK cells mediates antitumor effects.,Cancer Immunol Immunother.,2022 Aug 21

Chaoting Zhang#, Yizhe Sun#, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Nan Wu*, Zheming Lu*. Autophagic flux restoration enhances the antitumour efficacy of tumour infiltrating lymphocytes,Journal for ImmunoTherapy of Cancer,2022,10(10):e004868

Chaoting Zhang#, Yizhe Sun#, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Ping Zhou*, Zheming Lu* Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells.,Clin Transl Immunology. 2022,11(9):e1419

Cui L, Zhang C, Ding H, Feng D, Huang H, Lu Z*, Liu B*.Clonal Distribution and Intratumor Heterogeneity of the TCR Repertoire in Papillary Thyroid Cancer With or Without Coexistent Hashimoto's Thyroiditis.,Front Immunol.,2022 Jun 3

Shen Luyan, Xiao Yefei, Tian Jiahe, Lu Zheming*. Remodeling metabolic fitness: Strategies for improving the efficacy of chimeric antigen receptor T cell therapy.,Cancer Lett.,2022 Mar 31;529:139-152.

Shen Luyan, Xiao Yefei, Zhang Chaoting, Li Shance, Teng Xia, Cui Likun, Liu Ting, Wu Nan*, Lu Zheming. Metabolic reprogramming by ex vivo glutamine inhibition endows CAR-T cells with less-differentiated phenotype and persistent antitumor activity.,Cancer Lett.,2022 Jul 10;538:215710.

Chaoting Zhang#, Qin Tan#, Shance Li#, Luyan Shen, Jingtao Zhang, Ying Liu, Wenjun Yang*, Zheming Lu*,Journal for Immunotherapy of Cancer,2021,9(7):e002516

Hui Liu#, Wen Lei #, Chaoting Zhang#, Chunmei Yang , Juying Wei , Qunyi Guo , Xiaojun Guo , Zhilu Chen , Ying Lu, Ken H Young*, Zheming Lu* , Wenbin Qian*. CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma,Clinical Cancer Research,2021,27(2):473-484.

Liang Yun#, Liu Hui#, Lu Zheming#, Lei Wen, Zhang Chaoting, Li Ping, Liang Aibin*, Young Ken H*, Qian Wenbin* CD19 CAR-T expressing PD-1/CD28 chimeric switch receptor as a salvage therapy for DLBCL patients treated with different CD19-directed CAR T-cell therapies,J Hematol Oncol.,2021;14(1):26

Chaoting Zhang#, Heyilimu Palashati#, Zhuona Rong, Ningjing Lin, Luyan Shen, Ying Liu, Shance Li, Bentong Yu*, Wenjun Yang*, Zheming Lu* Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies,Molecular Cancer,2020,19(1):162

Ningjing Lin #, Wenjing Ku#, Yuqin Song, Jun Zhu*, Zheming Lu* Genome-Wide Analysis of Epstein-Barr Virus Isolated from Extranodal NK/T-Cell Lymphoma, Nasal Type,Oncologist,2019,24(9):e905-e913

Tan Qin, Zhang Chaoting*, Yang Wenjun, Liu Ying, Heyilimu Palashati, Feng Dongdong, Xing Liying, Ke Yang*, Lu Zheming* Isolation of T cell receptor specifically reactive with autologous tumour cells from tumour-infiltrating lymphocytes and construction of T cell receptor engineered T cells for esophageal squamous cell carcinoma.,Journal for immunotherapy of cancer,2019,7(1):232

张超亭,陆哲明* :个体化肿瘤特异TCR的筛选策略,中国肿瘤生物治疗杂志,2021, Vol. 28,863-868

一种同时表达靶向CD19和CD20的CAR与PD1-CD28嵌合受体的慢病毒载体, 发明专利, 第1完成人, 国家知识产权局, 中国, 2020.7

靶向TRBC1 CAR-T细胞的制备方法与应用, 发明专利, 第1完成人, 国家知识产权局, 中国, 2020.6

一种筛选肿瘤特异TCR的方法, 发明专利, 第1完成人, 国家知识产权局, 中国, 2022.6

CD19&PD1/CD28CAR-T 细胞治疗复发/难治B 细胞淋巴瘤患者的扩展性临床研究, 课题负责人, 2022.1.1~2024.12.31, 2022 年度首都卫生发展科研专项重点攻关项目

高效获得抗肿瘤TCR及其功能研究, 课题负责人, 2020.1.1~2023.12.31, 国家自然科学基金

抗肿瘤TCR的克隆及在食管鳞癌过继细胞治疗中的临床前研究, 课题负责人, 2017.1.1~2020.12.31, 北京市自然科学基金/7171001

免疫图谱动态检测预测肝癌Nivolumab治疗效果, 课题负责人, 2017.2.1~2020.8.31, 北京市科委“首都临床特色应用研究”专项/Z171100001017136

研究生招生计划
招生年度 招生专业 学位级别 学位类型 研究方向 选拔方式 操作
2024 肿瘤学 博士 科学学位 肿瘤细胞免疫治疗 申请考核制

社会任职

  • 中华抗癌学会病因学分会常务委员
  • 中国医药质量管理协会细胞治疗质量控制与研究专业委员会委员

学习、工作经历

  • 2022.8.1~,北京市肿瘤防治研究所(北京大学肿瘤医院) 生化与分子生物学研究室 教授
  • 2018.8.1~,北京市肿瘤防治研究所(北京大学肿瘤医院) 生化与分子生物学研究室 研究员
  • 2010.10.4~2018.7.31,北京市肿瘤防治研究所 副研究员
  • 2008.5.6~2010.9.6,北京市肿瘤防治研究所 助理研究员
  • 2006.7.14~2008.4.14,Duke University, Medical Center博士后