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导师基本信息

  • 姓名:孔燕
  • 性别:
  • 民族:汉族
  • 科室:黑色素瘤与肉瘤内科
  • 职称:研究员,教授
  • 专业:肿瘤学
  • E-MAIL: k-yan08@163.com

学术论文 | 科研项目

Jiayi Yu,Junya Yan,Qian GUO,Zhihong Chi,Bixia Tang,Bin Zheng,Jinyu YU,Ting Yin,Zhiyuan Cheng,Xiaowei Wu,Huan Yu,Jie Dai,Xinan Sheng,Lu Si,Chuangliang Cui,Xue Bai,Lili Mao,Bin Lian,Xuan Wang,Xieqiao Yan,Siming Li,Li Zhou,Keith,Jun Guo and Yan Kong#.Genetic aberrations in the CDK4 pathway sssociated with innate resistance to PD-1 blockade in Chinese patients with non-cutaneous melanoma,Clin Cancer Res,25(21): 6511-6523

Yang L,?Dai J,?Ma M,?Mao L,?Si L,?Cui C,?Sheng X,?Chi Z,?Yu S,?Xu T,?Yu J,?Kong Y,?Guo J.Identification of a functional polymorphism within the 3'-untranslated region of denticleless E3 ubiquitin protein ligase homolog associated with survival in acral melanoma..Sep;1,Eur J Cancer,118:70-81

Felicity Newell,Yan Kong#,James Wilmott,Peter Johansson,Peter Ferguson,Chuangliang Cui,Zhongwu Li,Stephen Kazakoff,Hazel Burke,Tristan Dodds,Ann-Marie Patch,Katia Nones,Varsha Tembe,Ping Shang,Louise van der Weyden,Kim Wong,Oliver Holmes,Serigne Lo,Conrad Leonard,Scott Wood,Qinying Xu,Robert Rawson,Pamela Mukhopadhyay,Reinhard Dummer,Mitchell Leesque,,Goran Jonsson,Xuan Wang,lwei Yeh,Hong Wu,Nancy Joseph,Boris Bastian,Georgina Long,Andrew Spillane,Kerwin Shannon,John Thompson,Robyn Saw,David Adams,Lu Si,John Pearson,Nicholas Hayward,Nicola Waddell,Graham,Jun Guo,and Richard Scolyer.Whole-genome landscape of mucosal melanoma reveals diverse and therapeutic targets,Nature Conmunication,10(1):3163

Yu J,?Xu L,?Yan J,?Yu J,?Wu X,?Dai J,?Guo J,?Kong Y# .MUC4 isoforms expression profiling and prognosis value in Chinese melanoma patients,Clin Exp Med,22(20);299-311

Dai J,?Yang L,?Xu T,?Si L,?Cui C,?Sheng X,?Chi Z,?Mao L,?Lian B,?Tang B,?Bai X,?Zhou L,?Li S,?Wang X,?Yan X,?Kong Y#,?Guo J.A Functional Synonymous Variant in?PDGFRA?Is Associated with Better Survival in Acral Melanoma,J Cancer,11(10):2945-2956

Yu J,?Yu J,?Wu X,?Guo Q,?Yin T,?Cheng Z,?Dai J,?Kong Y,?Guo J.The TERT copy number gain is sensitive to telomerase inhibitors in human melanoma.Clin Sci (Lond),Clin Sci (Lond),134(2):193-205

Yan J, Xu L, Yu J, Wu X, Dai J, Xu T, Yu H, Guo J,Kong Y# . Prognostic role of NRAS isoforms in Chinese melanoma patients,Melanoma research,29(3):263-269

Huan Tang,Meng Ma,Jie Dai,Chuanliang Cui,Lu Si,Xinan Sheng,Zhihong Chi,Longwen XU,Sifan Yu,Tianxiao Xu,Junya Yan,Huan Yu,Lu Yang,Yan Kong# and Jun Guo.miR-let-7b and miR-let-7c suppress tumourigenesis of human mucosal melanoma and enhance the sensitivity to chemotherapy.,J Exp Clin Cancer Res,38(1):212

Ma M, Dai J, Tang H, Xu T, Yu S, Si L, Cui C, Sheng X, Chi Z, Mao L, Wu X, Yang L, Yu H, Li S, Lian B, Tang B, Wang X, Yan X, Bai X, Zhou L,Kong Y* and Guo J*. MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways.,Theranostics,9(4): 945-960

Yu J, Wu X, Yan J, Yu J, Yin T,Dai J, Ma M, Xu T, Yu H, Xu L,Yang L,Cheng Z, Chi Z, Sheng X, Cui C, Guo J*, Kong Y*, potential mutations in uveal melanoma identified using targeted nest-generation sequencing.,Journal of Cancer,10(2):488-493

Yan J, Wu X, Yu J, Ma M, Yu H, Xu T, Tang H, Xu L, Dai J, Si L, Chi Z, Sheng X, Cui C, Guo J*, Kong Y*. Establishment and characterization of melanoma patient-derived xenograft models for preclinical evaluation of novel therapeutics.,Melanoma research,28(6):527-35

CDK4抑制剂Ribociclib联合MEK抑制剂曲美替尼治疗黑色素瘤的可行性及机制探索, 课题负责人, 2021.12.1~2023.10.31, 横向课题

Tigit分子在黑色素瘤的转化研究, 课题负责人, 2021.4.1~2021.12.31, 横向课题

CAF在黑色素瘤微环境中的作用研究, 课题负责人, 2021.8.1~2023.7.31, 横向课题

功能性人工免疫分子的临床前研究, 参加者, 2020.5.18~2024.12.31, 国家重点研发计划

TERT高拷贝介导PD-1单抗治疗肢端型黑色素瘤耐药的作用机制研究, 课题负责人, 2020.1.1~2022.12.31, 北京市自然科学基金

EZH2介导的CRTAC1沉默在粘膜型黑色素瘤发展中的作用及其临床意义, 课题负责人, 2019.8.16~2023.12.31, 国家自然科学基金

肢端及粘膜型黑色素瘤肿瘤特异性新抗原鉴定及个体化多肽疫苗的抗肿瘤作用研究, 课题负责人, 2019.8.1~2023.8.31, 首都临床诊疗技术研究及示范应用专项

粘膜型黑色素瘤中DGKζ的功能及其作为潜在治疗靶点的研究, 课题负责人, 2017.1.1~2021.12.31, 国家自然科学基金面上项目

基于驱动基因筛查的肢端及粘膜型黑色素瘤精准治疗模式, 课题负责人, 2015.12.1~2018.12.31, 北京市卫生系统高层次卫生技术人才队伍建设工程

社会任职

  • 头颈部黑色素瘤专业委员会常务委员

学习、工作经历

  • 2020.8.1~,北京肿瘤医院 研究员
  • 2012.7.3~2020.8.1,北京肿瘤医院 副研究员