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导师基本信息

  • 姓名:孔燕
  • 性别:
  • 民族:汉族
  • 科室:黑色素瘤与肉瘤内科
  • 职称:研究员,教授
  • 专业:肿瘤学
  • E-MAIL: k-yan08@163.com

学术论文 | 科研项目

Yong Jiang# , Anran Dai# , Yuwei Huang# , Hua Li# , Jian Cui #, Haochen Yang , Lu Si , Tao Jiao , Zhengxu Ren , Ziwei Zhang , Si Mou , Hengrui Zhu , Wenhui Guo , Qiang Huang , Yilin Li , Manman Xue , Jingwei Jiang , Fei Wang , Li Li , Qinying Zhong , Kun Wang , Baichuan Liu , Jinjiao Wang , Gaofeng Fan , Jun Guo , Liang Chen , Creg J Workman , Zhirong Shen , Yan Kong* , Dario A A Vignali *, Chenqi Xu* , Haopeng Wang*,Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs,Cell,2025 May 1;188(9):2354-2371.e18.

Fenghao Zhang # , Haizhen Du # , Kaiping Liu # , Qian Guo , Mengmeng Liang , Jing Shi , Shi Feng , Ting He , Xin-An Lu , Yanfang Tang , Lihua Wang , Qiaozhen Li , Xun Meng , Shu-Hui Liu , Yanping Ding , Yan Kong *MUC18-Directed chimeric antigen receptor T cells for the treatment of mucosal melanoma,J Transl Med,2025 Apr 24;23(1):473

Fenghao Zhang #, Xiaowen Wu#, Tao Jiao #, Haizhen Du #, Qian Guo , Chuanliang Cui , Zhihong Chi , Xinan Sheng , Dezhi Jiang , Yuhong Zhang , Jiayan Wu , Yan Kong *, Lu Si *,Genomic characterization reveals distinct mutational landscape of acral melanoma in East Asian,J Genet Genomics,2025 Apr;52(4):525-538.

Xuan Wang # , Hui Tian # , Zhihong Chi , Lu Si , Xinan Sheng , Han Hu , Xiangyong Gu , Siming Li , Caili Li , Bin Lian , Li Zhou , Lili Mao , Bixia Tang , Xieqiao Yan , Xiaoting Wei , Juan Li , Binlei Liu , Jun Guo , Yan Kong , Chuanliang Cui ,Oncolytic virus OH2 extends survival in patients with PD-1 pretreated melanoma: phase Ia/Ib trial results and biomarker insights,J Immunother Cancer,2025 Feb 6;13(2):e010662.

Shijie Fu #, Haizhen Du #, Yuyang Dai , Kanglian Zheng , Guang Cao , Liang Xu , Yujie Zhong , Chuanxin Niu , Yan Kong *, Xiaodong Wang *,Screening and molecular mechanism research on bile microRNAs associated with chemotherapy efficacy in perihilar cholangiocarcinoma,iScience,2024 Dec 4;27(12):111437.

Haizhen Du #, Lijie Hou #, Huan Yu , Fenghao Zhang , Ke Tong , Xiaowen Wu , Ziyi Zhang , Kaiping Liu , Xiangguang Miao , Wenhui Guo , Jun Guo* , Yan Kong *,Enhancer of Zeste Homolog 2 Protects Mucosal Melanoma from Ferroptosis via the KLF14-SLC7A11 Signaling Pathway,Cancers,2024 Oct 30;16(21):3660.

Xiaoyi Guo #, Muye Hu# , Qian Zhang , Jiayue Liu , Jing Shi , Yanfang Tang , ShuHui Liu , Jun Guo , Yan Kong *, Hua Zhu *, Zhi Yang *Preclinical ImmunoPET Imaging Using a Zr-89-Labeled Anti-CD146 Monoclonal Antibody for Diagnosis of Melanoma,Mol Pharm,2024 Sep 2;21(9):4490-4497

Junya Yan # , Shibo Wang # , Jing Zhang # , Qiangqiang Yuan , Xianchun Gao , Nannan Zhang , Yan Pan , Haohao Zhang , Kun Liu , Jun Yu , Linbin Lu , Hui Liu , Xiaoliang Gao , Sheng Zhao , Wenyao Zhang , Abudurousuli Reyila , Yu Qi , Qiujin Zhang , Shundong Cang , Yuanyuan Lu , Yanglin Pan , Yan Kong *, Yongzhan Nie *,DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation,Cancer Biol Med,2023 Dec 29;21(3):252-266.

Jing Shi # , Tao Jiao # , Qian Guo # , Weining Weng , Linjie Ma , Qing Zhang , Lijun Wang , Jianjian Zhang , Caiwei Chen , Yaling Huang , Mingqiao Wang , Rong Pan , Yanfang Tang , Wenhao Hu , Tao Meng , Shu-Hui Liu , Jun Guo , Yan Kong* , Xun Meng *A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody-Drug Conjugate for Targeting Melanoma,Cancer Res,2023 Nov 15;83(22):3783-3795

Yunxiao Duan #, Xiaowen Wu , Ziqi Gong , Qian Guo , Yan Kong *,Pathological impact and medical applications of electromagnetic field on melanoma: A focused review,Front Oncol,2022 Jul 22:12:857068

Qingfeng Shang #, Haizhen Du , Xiaowen Wu , Qian Guo , Fenghao Zhang , Ziqi Gong , Tao Jiao , Jun Guo *, Yan Kong *,FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma,J Exp Clin Cancer Res,2022 May 10;41(1):170.

Jing Hu#,Chuanliang Cui#,Wenxian Yang,Lihong Huang,Rongshan Yu,Siyang Liu,Yan Kong*.Using deep learning to predict anti-PD-1 response in melanoma and lung cancer patients from histopathology images.,Translational Oncology.,2021 Jan,14(1).

黑色素瘤表观遗传新靶点的鉴定与应用, 课题负责人, 2025.1.1~2027.12.31, “医学+X”领航计划

靶向TP53新生抗原的通用型TCR-T细胞免疫治疗的开发, 课题负责人, 2024.11.1~2027.12.31, 横向课题

预测黑色素瘤免疫治疗疗效的分子标志物研究, 课题负责人, 2024.11.1~2027.10.31, 研究型病房卓越临床研究计划项目

影响TIL疗法在恶性黑色素瘤中临床疗效的表观遗传机制研究, 课题负责人, 2024.10.1~2027.9.30, 北京市自然科学基金

探索PD-L1/4-1BB双抗治疗ICIs治疗失败黑色素瘤患者的机制研究, 课题负责人, 2025.3.1~2026.9.30, 横向课题

OH2在黑色素瘤中疗效生物标志物研究, 课题负责人, 2024.7.1~2025.12.31, 横向课题

亚洲恶性黑色素瘤患者TILs的功能和机制研究, 课题负责人, 2024.4.1~2025.11.30, 横向课题

BA1302在黑色素瘤中的抗肿瘤作用研究, 课题负责人, 2024.11.1~2025.9.30, 横向课题

ST-1898在黑色素瘤及肾癌中的药效学研究, 课题负责人, 2024.8.1~2025.5.31, 横向课题

功能性人工免疫分子的临床前研究, 参加者, 2020.5.18~2024.12.31, 国家重点研发计划

TERT高拷贝介导PD-1单抗治疗肢端型黑色素瘤耐药的作用机制研究, 课题负责人, 2020.1.1~2022.12.31, 北京市自然科学基金

EZH2介导的CRTAC1沉默在粘膜型黑色素瘤发展中的作用及其临床意义, 课题负责人, 2019.8.16~2023.12.31, 国家自然科学基金

肢端及粘膜型黑色素瘤肿瘤特异性新抗原鉴定及个体化多肽疫苗的抗肿瘤作用研究, 课题负责人, 2019.8.1~2023.8.31, 首都临床诊疗技术研究及示范应用专项

粘膜型黑色素瘤中DGKζ的功能及其作为潜在治疗靶点的研究, 课题负责人, 2017.1.1~2021.12.31, 国家自然科学基金面上项目

社会任职

  • 头颈部黑色素瘤专业委员会常务委员

学习、工作经历

  • 2020.8.1~,北京肿瘤医院 研究员
  • 2012.7.3~2020.8.1,北京肿瘤医院 副研究员