ZhihaoLu, JianlingZou, ShuangLi, MichaelJ.Topper, YongTao, HaoZhang, et al.Epigenetic therapy inhibits metastases by disrupting premetastatic niches.,Nature,2020, 579,284–290.

Zhihao Lu#, Yu Fang#, Chang Liu#, Xiaotian Zhang#, Xiaowei Xin, Yi He, Yanshuo Cao, Xi Jiao, Tianqi Sun, Ying Pang, Yanli Wang, Jun Zhou, Changsong Qi, Jifang Gong, Xicheng Wang, Jian Li, Lili Tang*, Lin Shen* Early Interdisciplinary Supportive Care in Patients With Previously Untreated Metastatic Esophagogastric Cancer: A Phase III Randomized Controlled Trial.,Journal of Clinical Oncology,2021

Zhihao Lu, Junye Wang, Yongqian Shu, et al. Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial,British Medical Jouranl,2022 Apr 19;377:e068714

Zhihao Lu, Huan Chen, Xi Jiao, Wei Zhou, Wenbo Han, Shuang Li, Chang Liu, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanyan Li, Jie Li, Yan Li, Malcolm Brock, Henghui Zhang, and Lin Shen. Prediction of immune checkpoint inhibition with immune oncology-related gene expression in gastrointestinal cancer using a machine learning classifier.,Journal for ImmunoTherapy of Cancer,2020; 8(2): e000631.

Zhihao Lu#, Huan Chen#, Xi Jiao#, Yujiao Wang#, Lijia Wu, Huaibo Sun, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Keyan Yang, Ying Hu, Beibei Mao, Lei Zhang, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang & Lin Shen. Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer.,Genome Medicine,Volume 13, Article number: 175 (2021)

Zhihao Lu, Huan Chen, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Lihong Wu,Jianing Yu, Wenbo Han, Huaibo Sun, Xi Jiao, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, and Lin Shen. Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer,Journal for ImmunoTherapy of Cancer,2020; 8(2): e000374.

Xi Jiao# , Xin Wei #, Shuang Li, Chang Liu, Huan Chen, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yujiao Wang, Yanni Wang, Na Zhuo, Henghui Zhang , Zhihao Lu*, Lin Shen*. A genomic mutation signature predicts the clinical outcomes of immunotherapy and characterizes immunophenotypes in gastrointestinal cancer,NPJ Precis Oncol,2021 May 4;5(1):36

Lu, Zhihao#; Zou, Jianling#; Hu, Ying#; Li, Shuang; Zhou, Tao; Gong, Jifang; Li, Jian; Zhang, Xiaotian; Zhou, Jun; Lu, Ming; Wang, Xicheng; Peng, Zhi; Qi, Changsong; Li, Yanyan; Li, Jie; Li, Yan; Zou, Jianyin; Du, Xiao; Zhang, Henghui*; Shen, Lin*; Serological Markers Associated With Response to Immune Checkpoint Blockade in Metastatic Gastrointestinal Tract Cancer.,JAMA Network Open,2(7): 0-e197621

S Li, J Zou, C Liu, X Jiao, J Gong, J Li, Z Wang, M Lu, Z Lu*, L Shen*. Baseline derived neutrophil-to-lymphocyte ratio as a prognostic biomarker for non-colorectal gastrointestinal cancer patients treated with immune checkpoint blockade.,Clinical Immunology,212(108345): 1-8.

Yujiao Wang# , Xi Jiao #, Shuang Li #, et al. Alterations in DNA damage response and repair genes as potential biomarkers for immune checkpoint blockade in gastrointestinal cancer,Cancer Biol Med,2021 Sep 28;j.issn.2095-3941.2020.0708

Zhihao Lu, Zhi Peng, Chang Liu, Zhenghang Wang, Yakun Wang, Xi Jiao, Jian Li, Lin Shen. Current status and future perspective of immunotherapy in gastrointestinal cancers,The Innovation,2020/8/10

麒麟科学技术奖——上消化道肿瘤精准治疗体系的建立, 优秀科技创新奖, 第1完成人, 北京科技人才研究会, 2021.3

中国抗癌协会科技奖, 一等奖, 第5完成人, 中国抗癌协会, 2020.12

消化系统肿瘤的精准免疫和靶向治疗

外泌体Rab10通过激活肺泡上皮细胞CCL2-CCR2信号通路参与食管癌术后肺转移前微环境形成的分子调控机制及潜在临床应用研究, 课题负责人, 2021.1.1～2024.12.31, 国家自然科学基金面上项目

食管鳞癌三级淋巴结构精准评估模型的建立及其对免疫治疗指导作用的探索, 课题负责人, 2022.1.1～2024.12.31, 国家自然科学基金重大研究计划培育项目

RNA化学修饰m6A调控上消化道肿瘤免疫微环境的功能与分子机制研究, 课题负责人, 2020.1.1～2021.12.31, 北京大学临床医学+X青年项目

低剂量5-Aza联合Entinostat靶向转移前微环境抑制食管癌肺转移的作用和机制探讨, 课题负责人, 2020.1.1～2021.12.31, 北京市医院管理局青年人才培养“青苗”计划

胃癌免疫治疗方案的优化研究, 参加者, 2018.7.1～2020.12.31, 国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项

表观遗传学药物抑制食管鳞癌肺转移的作用和机制探索, 课题负责人, 2019.1.1～2020.12.31, 北京市医院管理局消化内科学科协同发展中心

研究生招生计划

招生年度	招生专业	学位级别	学位类型	研究方向	选拔方式	操作
2024	肿瘤学	博士	科学学位	消化道肿瘤转化研究与基础研究	申请考核制
2024	肿瘤内科学	长学制	专业学位	临床技能训练与研究	长学制二级学科培养