Deng XX, Jiao YN , Hao HF, Xue D*, Bai CC*, Han SY*. Taraxacum mongolicum extract inhibited malignant phenotype of triple-negative breast cancer cells in tumor-associated macrophages microenvironment through suppressing IL-10 / STAT3 / PD-L1.,J Ethnopharmacol.,2021, 274:113978.

Zhao C#, Hao HF#, Zhao HY, Ren W, An G, Sun H, Han SY*, Li PP*. Marsdenia tenacissima extract promotes gefitinib accumulation in tumor tissues of non-small cell lung cancer (NSCLC) xenograft mice.,J Ethnopharmacol.,2020, 255: 112770

Li ZD#, Hao HF#, Tian WJ, Jiao YN, Deng XX, Han SY*, Han JY*. Nitric oxide, a communicator between tumor cells and endothelial cells, mediates the anti-tumor effects of Marsdenia Tenacissima extract (MTE).,J Ethnopharmacol.,2020, 250:112524.

Hao HF#, Tian WJ#, Pan CS, Jiao YN, Deng XX, Fan JY, Han JY, Han SY*, Wang M*, Li PP*. Marsdenia tenacissima extract dilated small mesenteric arteries via stimulating endothelial nitric oxide synthase and inhibiting calcium influx.,J Ethnopharmacol.,2019, 238:111847.

Jiao YN#, Wu LN#, Xue Dong#, Liu XJ, Tian ZH, Jiang ST, Han SY*, Li PP*. Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells.,Cancer Cell Int. ,2018,18:149.

Li XH, He XR, Zhou YY, Zhao HY, Zheng WX, Jiang ST, Zhou Q, Han SY*, Li PP*. Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells.,J Ethnopharmacol. ,206:55-64.

Zhao C, Zheng N, Yang F, Han SY*, Li PP*. A validated high-performance liquid chromatography-tandem mass spectrometry method for quantification of gefitinib and its main metabolites in xenograft mouse tumor: application to a pharmacokinetics study. Biomed Chromatogr. 2019, 33:e4638.,Biomed Chromatogr.,2019, 33:e4638.

Han SY, Zhao W, Han HB, Sun H, Xue D, Jiao YN, He XR, Jiang ST, Li PP*. Marsdenia tenacissima extract overcomes Axl- and Met-mediated erlotinib and gefitinib cross-resistance in non-small cell lung cancer cells.,Oncotarget ,8(34):56893-56905

Wang S, Fu JL, Hao HF, Jiao YN, Li PP*, Han SY*,Pharmacol Res,170:105728

Deng XX, Zhao SP, Liu XQ, Han L, Wang RZ, Hao HF, Jiao YN, Han SY*, Bai CC*. Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs.,Pharm Biol.,2020, 58(1): 410-416.

Zhao C, Han SY*, Li PP*. Pharmacokinetics of gefitinib: roles of drug metabolizing enzymes and transporters.,BENTHAM SCIENCE ,2017;14(2):282-288

Deng XX, Ye YY, Hao HF, JiaoYN, Han SY*, Bai CC*. Chemical constituent and chemotaxonomic study on the root of Anemone vitifolia Buch.-Ham.,Biochemical Systematics and Ecology.,2019, 87: 103955

Yu JE#, Han SY#, Wolfson B, Zhou Q*. The role of endothelial lipase in lipid metabolism, inflammation, and cancer.,Histol Histopathol,33(1):1-10

肿瘤微环境及中药的调节作用

中药提高抗肿瘤靶向药的疗效评价及机理研究

蒲公英提取物通过CUEDC2影响三阴乳腺癌干细胞干性抑制其恶性表型的分子机制, 课题负责人 , 2019.1.1～2022.12.31, 国家自然科学基金面上项目

消癌平注射液调控HDGF改善肺癌gefitinib耐药的活性成分及分子机制研究, 课题负责人 , 2017.1.1～2018.12.31, 国家自然科学基金面上项目（81673730）

消癌平注射液通过调控CYP450 代谢酶克服非小细胞肺癌吉非替尼耐药的作用机制研究, 课题负责人 , 2013.1.1～2016.12.31, 国家自然科学基金面上项目(81274148)

中药消癌平调节自噬信号通路提高非小细胞肺癌吉非替尼疗效的作用机制, 课题负责人 , 2015.1.1～2017.12.31, 北京市自然科学基金面上项目/7152034

北京市卫生系统215高级技术人才学科骨干层次资助, 课题负责人 , 2014.12.1～2017.12.31, 北京市卫生系统高层次卫生技术人才队伍建设工程/2014-3-063

研究生招生计划

招生年度	招生专业	学位级别	学位类型	研究方向	选拔方式
2022	中西医结合基础	硕士	科学学位	肿瘤微环境及中药的调节作用	全国统考