Ge S, Zhang Q, He Q, Zou J, Liu X, Li N, Tian T, Zhu Y, Gao J, Shen L*. Famitinib exerted powerful antitumor activity in human gastric cancer cells and xenografts.,Oncol Lett.,12: 1763-8.

Yuan J, Li Y, Tian T, Li N, Zhu Y, Zou J, Gao J, Shen L. Risk prediction for early-onset gastric carcinoma: a case-control study of polygenic gastric caner in Han Chinese with hereditary background.,Oncotarget.,7(23): 33608-15.

Li N, Zhang QY, Zou JL, Li ZW, Tian TT, Dong B, Liu XJ, Ge S, Zhu Y, Gao J, Shen L. miR-215 promotes malignant progression of gastric cancer by targeting RUNX1. ,Oncotarget. ,7(4): 4817-28.

Wei Q, Wang X, Gao J, Li J, Li J, Qi C, Li Y, Li Z, Shen L*. Clinicopathologic and molecular features of colorectal adenocarcinoma with signet-ring cell component.,PLoS One.,11(6): e0156659.

Tian T, Gao J, Li N, Li Y, Lu M, Li Z, Lu Z, Li J, Shen L. Circulating chromogranin A as a marker for monitoring clinical response in advanced gastroenteropancreatic neuroendocrine tumors. ,PLoS One. ,11(5): e0154679.

Li Z, Lai Y, Sun L, Zhang X, Liu R, Feng G, Zhou L, Jia L, Huang X, Kang Q, Lin D, Gao J, Shen L. PD-L1 expression is associated with massive lymphocyte infiltration and histology in gastric cancer. ,Hum Pathol. ,55: 182-9.

Liu D, Lu M, Li J, Yang Z, Feng Q, Zhou M, Zhang Z, Shen L. The patterns and timing of recurrence after curative resection for gastric cancer in China. ,World J Surg Oncol. ,14(1): 305-15.

Wang Q, Zhang X, Shen E, Gao J, Cao F, Wang X, Li Y, Tian T, Wang J, Chen Z, Wang J, Shen L. The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer. ,Cancer Lett. ,380(1): 20-30.

Li Y, Gong J, Zhang Q, Lu Z, Gao J, Li Y, Cao Y, Shen L. Dynamic monitoring of circulating tumour cells to evaluate therapeutic efficacy in advanced gastric cancer. 2016; ,Br J Cancer. ,114(2): 138-45.

Gao J, Li J, Li Y, Li Z, Gong J, Wu J, Liu N, Dong B, Qi C, Li J, Shen L. Intratumoral KIT mutational heterogeneity and recurrent KIT/PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors. ,Oncotarget. ,7(21): 30241-9.

Gong J, Liu T, Fan Q, Bai L, Bi F, Qin S, Wang J, Xu N, Cheng Y, Bai Y, Liu W, Wang L, Shen L. Optimal regimen of trastuzumab in combination with oxaliplatin/capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial. ,BMC Cancer. ,16:68-76.

Kou F, Lu Z, Li J, Zhang X, Lu M, Zhou J, Wang X, Gong J, Gao J, Li J, Li Y, Shen L. Pretreatment lymphopenia is an easily detectable predictive and prognostic marker in patients with metastatic esophagus squamous cell carcinoma receiving first-line chemotherapy. ,Cancer Med. ,5(5): 778-86.

Lu M, Yang Z, Feng Q, Yu M, Zhang Y, Mao C, Shen L, Tang J. The characteristics and prognostic value of signet ring cell histology in gastric cancer: A retrospective cohort study of 2199 consecutive patients.,Medicine (Baltimore).,95(27): e4052.

Wang J, Xu R, Li J, Bai Y, Liu T, Jiao S, Dai G, Xu J, Liu Y, Fan N, Shu Y, Ba Y, Ma D, Qin S, Zheng L, Chen W, Shen L*. Randomized multicenter phase III study of a modified docetaxel and cisplatin plus fluorouracil regimen compared with cisplatin and fluorouracil as first-line therapy for advanced or locally recurrent gastric cancer.,Gastric cancer,19(1): 234-44

J Gao#, N Li#, Y Dong, S Li, L Xu, X Li, Y Li, Z Li, SS Ng, JJ Sung, L Shen* and J Yu*. miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer. ,oncogene ,348

Li Y, Zhang X, Gong J, Zhang Q, Gao J, Cao Y, Wang DD, Lin PP, Shen L*. Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients withadvanced gastric cancer.,Chin J Cancer Res.,28(6):579-588.

Li Y, Zhang X, Gong J, Zhang Q, Gao J, Cao Y, Wang DD, Lin PP, Shen L*. Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer.,Chinese Journal of Cancer Research,2016;28(6):579-588.

Xicheng Wang, Qing Wei, Jing Gao, Jian Li, Jie Li, Jifang Gong, Yanyan Li, Lin Shen*. Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study.,Chinese Journal of Cancer,2017;36:81

Wang J, Li Q, Yuan J, Wang J, Chen Z, Liu Z, Li Z, Lai Y, Gao J, Shen L*. CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cellcarcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrest.,J Transl Med.,2017 Jun 2;15(1):127.

Jie Li, Ming Lu, Zhihao Lu1, Zhongwu Li, Yiqiang Liu, Li Yang, Jian Li, Xiaotian Zhang, Jun Zhou, Xicheng Wang, Jifang Gong, Jing Gao, Yan Li and Lin Shen*. Irinotecan plus cisplatin followed by octreotide long-acting release maintenance treatment in advanced gastroenteropancreatic neuroendocrine carcinoma: IPO-NEC study.,ONCOTARGET,2017;8(15):25669-25678.

政府特殊津贴, 政府特殊津贴, 第1完成人 , 中华人民共和国国务院, 2016.12

全国优秀科技工作者, 全国优秀科技工作者, 第1完成人 , 中国科学技术协会, 2016.5

第六届“中国女医师协会五洲女子科技奖”, 医务（卫生）管理科研创新奖, 第1完成人 , 中国女医师协会, 2019.10

北京学者, 北京学者, 第1完成人 , 北京市人才工作领导小组, 2019.12

XZP-3287在人源化食管鳞癌PDX模型中的疗效探索, 课题负责人 , 2016.7.1～2018.5.31, 吉林四环制药有限公司山东轩竹医药科技有限公司

CAN017肿瘤标记物NRG1和GNAZ在中国食管鳞癌患者中的表达分析, 课题负责人 , 2017.9.1～2018.1.31, 北海康成（北京）医药科技有限公司

HER3抗体咋人源化食管鳞癌细胞及PDX模型中的疗效及可能预测标志物探索, 课题负责人 , 2018.6.1～2019.12.31, 北海康成（北京）医药科技有限公司

盐酸希明替康个性化特征研究, 课题负责人 , 2019.7.1～2020.12.31, 中国科学院上海药物研究所

anti-PD-L1、CS3003、CS3002联合anti-PD-1在消化道肿瘤模型中的临床研究, 课题负责人 , 2019.4.30～2019.12.31, 横向

JAB-3068在消化道肿瘤模型中的临床前研究, 课题负责人 , 2019.4.30～2020.3.31, 北京加科思新药研发有限公司

基于单细胞组学的胃癌耐药相关循环肿瘤细胞分型及其临床监测价值, 课题负责人 , 2016.1.1～2018.12.31, 北京市自然科学基金

BIBW 2992在食管鳞癌细胞系及PDX模型中的作用研究, 课题负责人 , 2016.1.1～2019.6.30, 英国勃林格殷格翰

首创1类新药注射用绿原酸I/II期临床研究, 子课题负责人 , 2018.1.1～2019.12.31, 科技重大专项重大新药创制项目

外泌体miR-122表达下调通过激活RhoA/ROCK1通路参与胃癌腹膜转移的分子调控机制及潜在临床应用研究, 课题负责人 , 2018.9.20～2022.12.31, 国家自然科学基金

基于病理、影像及多组学智能预测胃癌抗HER2治疗疗效及耐药研究, 课题负责人 , 2019.12.1～2023.12.31, 国家自然科学基金

胃癌靶向治疗新技术研究 , 课题负责人 , 2017.1.1～2020.12.31, 科技部重点研发计划

基于单细胞组学的胃癌耐药相关循环肿瘤细胞分型及其临床监测价值 , 课题负责人 , 2016.1.1～2018.12.31, 北京市自然科学基金（7161002）

靶向c-Met诱导胃癌细胞自噬在肿瘤治疗中的作用及机制 , 课题负责人 , 2015.1.1～2018.12.31, 国家自然科学基金

人体消化道蛋白质组表达谱 , 子课题负责人 , 2015.4.1～2018.8.31, 973子课题

研究生招生计划

招生年度	招生专业	学位级别	学位类型	研究方向	选拔方式
2021	肿瘤内科学	长学制	专业学位	临床技能训练与研究	长学制二级学科培养
2021	肿瘤内科学	博士	专业学位	临床技能训练与研究	申请考核制