Zilei Wang#, Chuanke Zhao#, Jin Ding, Yan Chen, Jiayue Liu, Xingguo Hou, XiangXing Kong, Bin Dong, Zhi Yang, Hua Zhu*. Screening, Construction, and Preliminary Evaluation of CLDN18.2-Specific Peptides for Noninvasive Molecular Imaging.,ACS Pharmacol Transl Sci.,6(12):1829-1840.

Zilei Wang#, Chuanke Zhao#, Chuangui Li#, Song Liu, Jin Ding, Chengxue He, Jiayue Liu, Bin Dong, Zhi Yang, Qi Liu*, Hua Zhu*, Youping Liu*. Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy.,J Med Virol.,95(11):e29221.

Qian Guo#, Chuanke Zhao#, Xiangyu Gao#, Lixin Ding, Pei Wang, Ya'nan Ren, Xingguo Hou, Yuan Yao, Cheng Zhang*, Xianteng Yang*, Zhi Yang* , Hua Zhu*. One-Minute Iodine Isotope Labeling Technology Enables Noninvasive Tracking and Quantification of Extracellular Vesicles in Tumor Lesions and Intact Animals.,Mol Pharm.,20(7):3672-3682.

Shan-Mei Chen, Chuan-Ke Zhao*, Li-Cheng Yao, Li-Xin Wang, Yu-Nan Ma, Lin Meng, Shao-Qing Cai, Cai-Yun Liu, Li-Ke Qu*, Yan-Xing Jia* and Cheng-Chao Shou*. A potent multi-targeting stilbenolignan, Aiphanol, blocks lymphangiogenesis and lymphatic metastasis. Acta Pharmacologica Sinica, 2023 Jan;44(1):189-200.,Acta Pharmacologica Sinica,44(1):189-200.

Shan-Mei Chen, Jun-Nan Feng, Chuan-Ke Zhao*, Li-Cheng Yao, Li-Xin Wang, Lin Meng, Shao-Qing Cai, Cai-Yun Liu, Li-Ke Qu*, Yan-Xing Jia* and Cheng-Chao Shou*. A multi-targeting natural product, aiphanol, inhibits tumor growth and metastasis. American Journal of Cancer Research. 2022 Nov 15; 12(11):4930-4953.,American Journal of Cancer Research,12(11):4930-4953.

Chuanke Zhao#, Zhuona Rong#, Jin Ding#, Lixin Wang, Bing Wang, Lei Ding, Lin Meng, Xiangxi Meng, Feng Wang, Zhi Yang, Chengchao Shou and Hua Zhu*..Targeting Claudin 18.2 Using a Highly Specific Antibody Enables Cancer Diagnosis and Guided Surgery. Mol Pharmaceutics, 2022 Oct 3;19(10):3530-3541.,Mol Pharmaceutics,,19(10):3530-3541.

Shanmei Chen, Junnan Feng, Chuanke Zhao*, Lixin Wang, Lin Meng, Caiyun Liu, Shaoqing Cai, Yanxing Jia, Like Qu* and Chengchao Shou*. Aiphanol, a native compound, suppresses angiogenesis via dual-targeting VEGFR2 and COX2. Signal Transduction and Targeted Therapy, 2021 Dec 3;6(1):413.,Signal Transduction and Targeted Therapy,6(1):413

Boyang Cheng, Xindang Chu, Ruiwen Liu, Xinyuan Ma, Mengyang Wang, Jiayi Zhang, Pingxuan Jiao, Qianqian Gao, Wenxiao Ma, Yongmin Zhang, Chuanke Zhao*, Demin Zhou and Sulong Xiao*. Synthesis of Novel Pentacyclic Triterpenoid Derivatives that Induce Apoptosis in Cancer Cells through a ROS-dependent, Mitochondrial-Mediated Pathway. Mol Pharmaceutics, 2023 Jan 2;20(1):701-710.,Mol Pharmaceutics,,2023 Jan 2;20(1):701-710.

Jinping Tao#, Ziqing Zeng#, Chengxue He#, Lin Meng, Wenyuan Zhou, Ya’nan Ren, Xiaopan Ma, Zilei Wang, Jiayue Liu, Dapeng Li, Qian Zhang, Chuanke Zhao*, Zhi Yang*, Hua Zhu*. Construction and Preclinical Evaluation of 124/125I-Labeled Antibody Targeting T Cell Immunoglobulin and Mucin Domain-3.,Molecular Pharmaceutics,21(2): 944-956

靶向免疫检查点TIM3结合肽及其应用。, 发明专利, 第2完成人, 国家知识产权局, 中国, 2022.3

Aiphanol在抗肿瘤中的应用。, 发明专利, 第3完成人, 国家知识产权局, 中国, 2019.12

血管内皮细胞生长因子受体拮抗肽F56的衍生物及应用。, 发明专利, 第2完成人, 国家知识产权局, 中国, 2021.9

基于三代EGFR-TKI 耐药肺腺癌类器官库的精准靶向治疗关键技术研究, 子课题负责人, 2023.1.1～2025.12.31, 江西省科学技术厅，重点研发计划

基于天然产物Aiphanol的结构优化及抗肿瘤作用机制研究, 课题负责人, 2022.1.1～2022.12.31, 北京大学2022年度临床医学+X青年专项

靶向VEGF/SNCG双特异抗体的应用及转化研究, 课题负责人, 2023.1.1～2023.12.31, 北京大学肿瘤医院科创项目

以VEGF 受体为靶点的长效修饰肽在消化系统肿瘤治疗与分子显像中的应用基础研究, 课题负责人, 2019.1.1～2022.12.31, 北京市医管局

研究生招生计划

招生年度	招生专业	学位级别	学位类型	研究方向	选拔方式	操作
2025	医学生物化学与分子生物学	硕士	科学学位	抗肿瘤药物的开发与应用基础研究	全国统考