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导师基本信息

  • 姓名:朱华
  • 性别:
  • 民族:汉族
  • 科室:核医学科
  • 职称:研究员
  • 专业:影像医学与核医学
  • E-MAIL: zhuhuaBCH@pku.edu.cn

学术论文 | 综述述评 | 出版专著 | 奖励表彰 | 研究方向 | 科研项目 | 招生计划

Xingguo Hou#, Song Liu, Ziqing Zeng, Zilei Wang, Jin Ding, Yan Chen, Xiangyu Gao, Jianghua Wang, Guanxi Xiao, Baiyong Li, Hua Zhu*, Zhi Yang*. Preclinical imaging evaluation of a bispecific antibody targeting hPD1/CTLA4 using humanized mice.,Biomedicine and Pharmacotherapy.,Apr 26:175:116669.

Ya'nan Ren#, Teli Liu#, Siming Li#, Xiaokun Ma, Lei Xia, Pei Wang, Qian Guo, Yuan Yao, Xingguo Hou, Xi'nan Sheng*, Hua Zhu*, Zhi Yang*. An iodine?labelled Antibody–drug conjugate PET probe for noninvasive monitoring of Nectin-4 expression in urothelial carcinoma.,International Journal of Pharmaceutics,,651, 123756.

Dapeng Li#, Lei Ding#, Yan Chen, Zilei Wang, Ziqing Zeng, Xiaopan M, Haifeng Huang, Hongjun Li, Xueming Qian*, Zhi Yang*, Hua Zhu*. Exploration of radionuclide labeling of a novel scFv-Fc fusion protein targeting CLDN18.2 for tumor diagnosis and treatment.,European Journal of Medicinal Chemistry,,266, 116134.

Jinping Tao#, Ziqing Zeng#, Chengxue He#, Lin Meng, Wenyuan Zhou, Ya’nan Ren, Xiaopan Ma, Zilei Wang, Jiayue Liu, Dapeng Li, Qian Zhang, Chuanke Zhao*, Zhi Yang*, Hua Zhu*. Construction and Preclinical Evaluation of 124/125I-Labeled Antibody Targeting T Cell Immunoglobulin and Mucin Domain-3.,Molecular Pharmaceutics,21(2): 944-956

Song Liu#, Teli Liu#, Wei Tian#, Qian Zhang, Zilei Wang, Xingguo Hou, Yanan Ren, Wanpu Yan, Meng Xu, Hongbin Han*, Hua Zhu*. Unique role of molecular imaging probes for viral infection.,TrAC Trends in Analytical Chemistry,,170, 117470.

Ziqing Zeng#, Liqiang Li#, Jinping Tao, Jiayue Liu, Jinping Tao, Hongjun Li, Xueming Qian, Zhi Yang*, Hua Zhu*. [177Lu]Lu-labeled anti-claudin-18.2 antibody demonstrated radioimmunotherapy potential in gastric cancer mouse xenograft models.,European Journal of Nuclear Medicine and Molecular Imaging.,51:1221-1232.

Zilei Wang#, Chuanke Zhao#, Chuangui Li#, Song Liu, Jin Ding, Chengxue He, Jiayue Liu, Bin Dong, Zhi Yang, Qi Liu*, Hua Zhu*, Youping Liu*. Molecular PET/CT mapping of rhACE2 distribution and quantification in organs to aid in SARS-CoV-2 targeted therapy.,Journal of Medical Virology,,95:e29221.

Zilei Wang#, Chuanke Zhao#, Jin Ding, Yan Chen, Jiayue Liu, Xingguo Hou, XiangXing Kong, Bin Dong, Zhi Yang, Hua Zhu*. Screening, construction and preliminary evaluation of CLDN18.2-specific peptides for noninvasive molecular imaging.,ACS Pharmacology & Translational Science.,6(12):1829-1840.

Yang Liu#, Ya-nan Ren#, Yan Cui, Song Liu, Zhi Yang, Hua Zhu*. Nan Li*. Inspired by novel radiopharmaceuticals: Rush hour of nuclear medicine.,Chin J Cancer Res,35(5): 470-482.

Yuan Yao#, Yanan Ren, Xingguo Hou, Jinyu Zhu, Xiaokun Ma, Song Liu, Teli Liu, Qian Zhang , Xiaopan Ma, Zhi Yang*, Hua Zhu*, Nan Li*. Construction and preclinical evaluation of a zirconium-89 labelled monoclonal antibody targeting PD-L2 in lung cancer.,Biomed Pharmacother.,168, 115602.

Xiaokun Ma#, Teli Liu#, Ya’nan Ren, Xiaopan Ma, Yuan Yao, Xinguo Hou, Jin Ding, Feng Wang, Haifeng Huang, Hua Zhu*, Zhi Yang*. 124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies.,Acta Pharmacologica Sinica,,45(2):436-448

Yan Chen#, Zhi Yang, Xueyun Gao*, Hua Zhu*, CLDN18.2-targeted molecular imaging and precision therapy of gastrointestinal tumors,Journal of Pharmaceutical Analysis,13(9):955-957

Xiaopan Ma#, Xin Zhou#, Biao Hu#, Xiaoda Li, Meinan Yao, Liqiang Li, Xue Qin, Dapeng Li, Yuan Yao, Xingguo Hou, Song Liu, Yan Chen, Zilei Wang, Wenyuan Zhou, Nan Li*, Hua Zhu*, Bing Jia*, Zhi Yang*. Preclinical evaluation and pilot clinical study of [68Ga]Ga?THP?APN09, a novel PD?L1 targeted nanobody radiotracer for rapid one?step radiolabeling and PET imaging,European Journal of Nuclear Medicine and Molecular Imaging,50(13): 3838-3850

Qian Guo, Chuanke Zhao, Xiangyu Gao, Lixin Ding, Pei Wang, Ya'nan Ren, Xingguo Hou, Yuan Yao, Cheng Zhang*, Xianteng Yang*, Zhi Yang*, Hua Zhu*. One-Minute Iodine Isotope Labeling Technology Enables Noninvasive Tracking and Quantification of Extracellular Vesicles in Tumor Lesions and Intact Animals,molecular pharmaceutics,2023 May 22. doi: 10.1021/acs.molpharmaceut.3c00299

陶金萍#, 黄海峰, 杨志, 朱华*. 基于免疫检查点抗体药物的分子探针的应用.,肿瘤影像学,32(2), 122-131.

Lei Xia#, Chengxue He#, Yanhui Guo#, Xiangxi Meng, Teli Liu, Xiaoxia Xu, Xiaoyi Guo, Feng Wang, Nan Li*, Hua Zhu*, Zhi Yang*. Preparation and Application of a Bioorganic Nanoparticle-Enhanced PDL1-Targeted Small-Molecule Probe.,ACS Appl Mater Interfaces,15(25):30619-30629.

Shujing Wang#, Changsong Qi#, Jin Ding#, Dan Li, Miao Zhang, Concong Ji, Fangli Jiang, Fei Teng, Jie Yu, Xueming Qian, Feng Wang, Lin Shen, Jing Gao*, Zhi Yang*, Cheng Zhang*, Hua Zhu*. First-in-Human CLDN18.2 Functional Diagnostic PET Imaging of Digestive System Neoplasms Enables Whole-Body Target Mapping and Lesion Detection.,European Journal of Nuclear Medicine and Molecular Imaging.,50(9):2802-2817

Xiaojiang Duan#, Lei Xia#, Zhuochen Zhang#, Yanan Ren, Martin G. Pomper, Steven P. Rowe, Xuesong Li, Nan Li, Ning Zhang, Hua Zhu*, Zhi Yang*, Xinan Sheng*, Xing Yang*. First-in-human study of the radioligand 68Ga-N188 targeting nectin-4 for PET/CT imaging of advanced urothelial carcinoma.,Clinical Cancer Research.,CCR-23-0609

Jiayue Liu#, Xiaoyi Guo#, Li Wen, Lixin Wang, Futao Liu, Guohong Song, Hua Zhu*, Nina Zhou*, Zhi Yang* Comparison of renal clearance of [18F]AlF-RESCA-HER2-BCH and [18F]AlF-NOTA-HER2-BCH in mice and breast cancer patients,European journal of nuclear medicine and molecular imaging,published online ahead of print

Yan Chen#, Xingguo Hou#, Dapeng Li#, Jin Ding, Jiayue Liu, Zilei Wang, Fei Teng, Hongjun Li, Fan Zhang, Yi Gu, Steven Yu, Xueming Qian*, Zhi Yang*, Hua Zhu*. Development of a CLDN18.2-targeting Immuno-PET Probe for Non-invasive Imaging in Gastrointestinal Tumors.,Journal of Pharmaceutical Analysis,13(4): 367-375

朱华#, 任亚楠, 杨志*. 中国智造:新型18F标记 PSMA PET探针及其在前列腺癌临床中的转化.,中华核医学与分子影像杂志.,43(4): 193-195

Yuan Yao*, Xingguo Hou*, Song Liu, Teli Liu, Yanan Ren, Xiaokun Ma, Qian Zhang, Pei Wang, Qian Guo, Xiaopan Ma, Zhi Yang#, Hua Zhu#, Nan Li#. Construction and Preclinical Evaluation of a 124/125I-Labeled Specific Antibody Targeting PD-L2 in Lung Cancer,Molecular Pharmaceutics,20, 1365-1374

Pei Wang*, Shuailiang Wang*, Futao Liu*, Ya’nan Ren, Qian Guo, Qian Zhang, XingGuo Hou, Yuan Yao, Hua Zhu#, Zhi Yang#. Preclinical Evaluation of a Fibroblast Activation Protein and a Prostate-Specific Membrane Antigen Dual-Targeted Probe for Noninvasive Prostate Cancer Imaging,Molecular Pharmaceutics,20, 2, 1415-1425

Chuanke Zhao#, Zhuona Rong#, Jin Ding#, Lixin Wang, Bing Wang, Lei Ding, Lin Meng, Xiangxi Meng, Feng Wang, Zhi Yang, Chengchao Shou, Hua Zhu*. Targeting Claudin 18.2 Using a Highly Specific Antibody Enables Cancer Diagnosis and Guided Surgery,Molecular Pharmaceutics,19, 3530−3541

Song Liu#, Guanghui Li#, Lei Ding#, Jin Ding, Qian Zhang, Dan Li, Xingguo Hou, Xiangxing Kong, Jing Zou, Shiming Zhang, Hongbin Han*, Yakun Wan*, Zhi Yang*, Hua Zhu*. Evaluation of SARS-CoV-2-neutralizing Nanobody Using Virus 11Receptor Binding Domain Administered Model Mice,Research,9864089.

Lei Xia, Xiangxi Meng, Li Wen, Nina Zhou, Teli Liu, Xiaoxia Xu, Feng Wang, Zhen Cheng, Zhi Yang*, Hua Zhu*. A Highly Specific Multiple Enhancement Theranostic Nanoprobe for PET/MRI/PAI Image-Guided Radioisotope Combined Photothermal Therapy in Prostate Cancer.,Small,17(21), 2100378

Nina Zhou#, Chang Liu#, Xiaoyi Guo#, Yuping Xu, Jifang Gong, Changsong Qi, Xiaotian Zhang, Ming Yang*, Hua Zhu*, Lin Shen*, Zhi Yang*. 68Ga-NOTA-MAL- MZHER2 PET Imaging in advanced gastric cancer patients and therapeutic response monitoring.,European Journal of Nuclear Medicine and Molecular Imaging,,2021, 48, 161-175

Shujing Wang#, Hua Zhu#,*, Jin Ding, Feng Wang, Lixin Ding, Yan Zhang, Nan Li, Sheng Yao, Xinan Sheng*, Zhi Yang*. Positron Emission Tomography Imaging of Programmed Death 1 Expression in Cancer Patients Using Iodine-124 Labeled Toripalimab: A Pilot Clinical Translation Study.,Clinical Nuclear Medicine,2021, 46(5), 382-388

Hua Zhu#, Teli Liu#, Changhao Liu, Jing Wang, Hong Zhang, Bin Dong, Jing Shen, Chuanke Zhao, Zhenfu Li, Zhen Cheng*, Zhi Yang*. Evaluation of a novel monoclonal antibody mAb109 by immuno-PET/fluorescent imaging for noninvasive lung adenocarcinoma diagnosis.,Acta Pharmacologica Sinica.,2020, 41, 101-109. (Q1, SCI 4.01)

Xiaoyi Guo#, Nina Zhou#, Zuhua Chen#, Teli Liu, Xiaoxia Xu, Xia Lei, Lin Shen, Jing Gao, Zhi Yang*, Hua Zhu*. Construction of 124I-trastuzumab for Noninvasive PET Imaging of HER2 Expression: From Patient-derived Xenograft Models to Gastric Cancer Patients.,Gastric Cancer.,2020. 23:614-626. (SCI IF 5.55 Q1 )

Chen Liu#, Teli Liu#, Zhongyi Zhang#, Ning Zhang, Peng Du, Yong Yang, Yiqiang Liu, Wei Yu, Nan Li, Michael A Gorin, Steven P. Rowe*, Hua Zhu*, Kun Yan*, Zhi Yang*. PSMA PET/CT and standard plus PET/CT-Ultrasound fusion targeted prostate biopsy can diagnose clinically significant prostate cancer in men with previous negative biopsies.,Journal of Nuclear Medicine,,2020. 61:1314-1319.

Nina Zhou#, Xiaoyi Guo#, Min Yang, Hua Zhu*, Zhi Yang*.68Ga-ZHER2 PET/CT Reveals HER2-positive Metastatic Gastric Cancer with Better Image Quality than 18F-FDG.,Clinical Nuclear Medicine,,2020, DOI 10.1097/RLU.0000000000002859. (SCI IF 6.5 Q1 )

Xiaoxia Xu?, Hua Zhu?, Fei Liu, Yan Zhang, Jianhua Yang, Lifang Zhang, Qing Xie, Lin Zhu, Nan Li*, Hank F. Kung*, Zhi Yang*. Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in healthy volunteers and oncological patients.,European Journal of Nuclear Medicine and Molecular Imaging,,2020, DOI: 10.1007/s00259-019-04543-w. (SCI IF 7.7 Q1 )

Haifeng Huang?, Hua Zhu?, Quan Xie, Xiao-Bin Tian, Xian-Teng Yang, Fan Feng, Qi-Yu Jiang, Xi-Nan Sheng, Zhi Yang*. Evaluation of 124I-JS001 for hPD1 immuno-PET imaging using sarcoma cell homografts in humanized mice.,Acta Pharmaceutica Sinica B.,2020, DOI: 10.1016/j.apsb.2020.02.004. (SCI IF 6.01 Q1 )

Fei Liu, Xiaoyi Guo, Teli Liu, Xiaoxia Xu, Nan Li, Chiyi Xiong, Chun Li, Hua Zhu*, Zhi Yang*. Evaluation of Pan-SSTRs Targeted Radioligand [64Cu]NOTA-PA1 Using Micro-PET Imaging in Xenografted Mice.,ACS Med. Chem. Lett.,2020, 11, 445-450. (SCI IF 3.74, Q2)

王风,郭晓轶,刘特立,丁立新,夏雷,丁缙,孟祥溪,蒋金泉,朱华*,杨志. 固体靶PET核素89Zr的制备、质控和抗体标记.,中华核医学与分子影像杂志,2020, 40 (5):294-297.

Xudong Wang?, Feng Wang?, Jintao Han, Zhi Yang, Hua Zhu,* Gen Yang*. Construction and Preclinical Evaluation of a 124/131I?Labeled Radiotracer for the Detection of Mesothelin-Overexpressing Cancer. Molecular Pharmaceutics. 2020. 17, 1875-1883. (Q1, SCI, 4.4),Molecular Pharmaceutics,. 2020. 17, 1875-1883. (Q1, SCI, 4.4)

Nina Zhou?, Chang Liu?, Xiaoyi Guo?, Yuping Xu, Jifang Gong, Changsong Qi, Xiaotian Zhang, Ming Yang*, Hua Zhu*, Lin Shen*, Zhi Yang*. 68Ga-NOTA-MAL- MZHER2 PET Imaging in advanced gastric cancer patients and therapeutic response monitoring.,European Journal of Nuclear Medicine and Molecular Imaging,,2020, DOI: 10.1007/s00259-020-04898-5. (SCI IF 7.7 Q1 )

Chuanke Zhao#, Zhuona Rong#, Jin Ding#, Lixin Wang, Bing Wang, Lei Ding, Lin Meng, Xiangxi Meng, Feng Wang, Zhi Yang, Chengchao Shou, Hua Zhu*. Targeting Claudin 18.2 Using a Highly Specific Antibody Enables Cancer Diagnosis and Guided Surgery,Molecular Pharmaceutics,34

Xiangxi Meng, Hui Liu, Hui Li, Shujing Wang, Hongwei Sun, Feng Wang, Jin Ding, Liuchun He, Xin Chen, Lujia Jin, Yun Dong, Hua Zhu*, Zhi Yang*. Evaluating the impact of different positron emitters on the performance of a clinical PET/MR system,Medical Physics,49(4):2642-2651

冯中政, 孙华, 陈龙, 陈东雪, 朱华*。 新型分子探针指导肺癌精准诊疗,肿瘤综合治疗电子杂志,8(1):43-47

Xue Qin, Xiangxi Meng, Yao Xiong, Xiaoyi Guo, Yanan Ren, Li Wen, Qian Zhang, Hua Zhu*, Zhi Yang*. Initial evaluation of 99mTc-labeled anti-CEA scFv for micro-SPECT imaging in mice with colorectal cancer.,Journal of Labelled Compounds and Radiopharmaceuticals,65(3):63-70

Lei Xia#, Li Wen#, Xiangxi Meng, Nina Zhou, Xiaoyi Guo, Teli Liu, Xiaoxia Xu, Feng Wang, Hua Zhu*, Zhi Yang*. Application analysis of 124I-PPMN for enhanced retention in tumors of prostate cancer xenograft mice,International Journal of Nanomedicine,16, 7685–7695

Dan Li#, Jin Ding#, Te-li Liu, Feng Wang, Xiang-xi Meng, Song Liu, Zhi Yang*, Hua Zhu*. SARS-CoV-2 receptor binding domain radio-probe: A non-invasive approach for angiotensin-converting enzyme 2 mapping in mice,Acta Pharmaceutica Sinica,43,1749–1757

朱华, 杨志*. 肿瘤新型放射性药物的研发与应用,中华核医学与分子影像杂志,41(10):577-579

张倩,丁缙, 任亚楠, 文丽, 秦雪, 朱华*, 杨志. 靶向血管紧张素转化酶2新型PET探针的制备及其肿瘤特异性分子显像,中华核医学与分子影像杂志,41(10):580-584

Xiaojiang Duan#, Zhen Cao#?, Hua Zhu#?, Chen Liu, Xiaojun Zhang, Jinming Zhang, Yanan Ren, Futao Liu, Xuekang Cai, Xiaoyi Guo, Zhen Xi, Martin G. Pomper, Zhi Yang*, Yan Fan*, Xing Yang*. 68Ga-Labeled ODAP-Urea-based PSMA Agents in Prostate Cancer: First-in-1 human Imaging of An Optimized Agent,European Journal of Nuclear Medicine and Molecular Imaging,49(3):1030-1040

Xin Zhou#, Jinquan Jiang#, Xue Yang#, Teli Liu, Jin Ding, Sridhar Nimmagadda, Martin G Pomper, Hua Zhu*, Jun Zhao*, Zhi Yang*, Nan Li*. First-in-human evaluation of a PD-L1-binding peptide radiotracer in non-small cell lung cancer patients with PET,Journal of Nuclear Medicine,63:536–542

Shujing Wang#, Hua Zhu#, Yingjie Li#, Jin Ding, Feng Wang, Lixin Ding, Xinyu Wang, Jun Zhao, Yan Zhang, Yunfeng Yao, Tong Zhou, Nan Li*, Aiwen Wu*, Zhi Yang*. First-in-Human DR5 PET Reveals Insufficient DR5 Expression in GI Cancer Patients,Journal for ImmunoTherapy of Cancer,9(7), e002926

Shuailiang Wang, Xin Zhou, Xiaoxia Xu, Jin Ding, Song Liu, Xingguo Hou, Nan Li, Hua Zhu*, Zhi Yang*. Clinical Translational Evaluation of Al18F-NOTA-FAPI for Fibroblast Activation Protein Targeted Tumour Imaging,European Journal of Nuclear Medicine and Molecular Imaging,48(13), 4259-4271

Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu*, Zhi Yang*, Zhaofei Liu*. Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy,Journal of Nanobiotechnology,19:175

Hua Zhu#,*, Hanwen Zhang#, Nina Zhou#, Jin Ding, Jinquan Jiang, Teli Liu, Ziyu Liu, Feng Wang, Qian Zhang, Zhuochen Zhang, Shi Yan, Lei Li, Nadia Benabdallah, Hongjun Jin, Zhaofei Liu, Lisheng Cai, Daniel LJ Thorek*, Xing Yang*, Zhi Yang*. Molecular PET/CT profiling of ACE2 expression in vivo: implications for infection and outcome from SARS-CoV-2,Advanced Science,8(16): 2100965

Teli Liu#, Chen Liu#, Zhongyi Zhang#, Ning Zhang, Xiaoyi Guo, Lei Xia, Jinquan Jiang, Qing Xie, Kun Yan, Steven P. Rowe*, Hua Zhu*, Zhi Yang*. 64Cu-PSMA-BCH: A new radiotracer for delayed PET imaging of prostate cancer,European Journal of Nuclear Medicine and Molecular Imaging,48:4508-4516

Zilei Wang#, Ziyu Liu#, Lanxin Yang#, Jin Ding, Feng Wang, Teli Liu, Zhi Yang, Chao Wang*, Hua Zhu*, Youping Liu*. Noninvasive Mapping of Angiotensin Converting Enzyme-2 in Pigeons Using Micro Positron Emission Tomography,Life,12(6), 793

Xue Qin#, Xiaoyi Guo#, Tianyu Liu, Liqiang Li, Nina Zhou, Xiaopan Ma, Xiangxi Meng, Jiayue Liu, Hua Zhu*, Bing Jia*, Zhi Yang*. High in-vivo Stability in Preclinical and First-in-human Experiments with [18F]AlF-RESCA-MIRC213: A 18F-Labeled Nanobody as PET Radiotracer for Diagnosis of HER2-Positive Cancers,Eur J Nucl Med Mol Imaging,

Qian Zhang#, Teli Liu#, Jin Ding, Nina Zhou, Ziyi Yu, Yanan Ren, Xue Qin, Peng Du*, Zhi Yang*, Hua Zhu*. Evaluation of 68Ga-and 177Lu-Labeled-HZ20 Angiotensin-Converting Enzyme 2-Targeting Peptides for Tumor Specific Imaging,Molecular Pharmaceutics,

Dan Li #, Feng Wang #, Jinquan Jiang, Xingguo Hou#, Jin Ding, Zilei Wang, Yan Chen, Teli Liu, Zhi Yang*, Hua Zhu*. Construction of a I-124-Labeled Specific Antibody for the Noninvasive Detection of Mesothelin-Overexpressing Tumors,Molecular Pharmaceutics,

Zhou X#, Wang S#, Xu X#, Meng X, Zhang H, Zhang A, Song Y, Zhu H, Yang Z*, Li N*. Higher accuracy of [68 Ga]Ga-DOTA-FAPI-04 PET/CT comparing with 2-[18F]FDG PET/CT in clinical staging of NSCLC,Eur J Nucl Med Mol Imaging,49:2983–2993

丁缙,李大鹏,张倩,孟祥溪,刘特立,杨志*,朱华*. 冠状病毒相关靶点的 PET 成像研究进展.,药学进展,,2023, 47(6): 464-470.

陶金萍, 黄海峰, 杨志, 朱华*. 基于免疫检查点抗体药物的分子探针的应用.,肿瘤影像学,2023, 32(2), 122-131.

朱华, 任亚楠, 杨志*. 中国智造:新型18F标记 PSMA PET探针及其在前列腺癌临床中的转化.,中华核医学与分子影像杂志.,2023, 43(4): 193-195.

冯中政, 孙华, 陈龙, 陈东雪, 朱华*. 新型分子探针指导肺癌精准诊疗. 2022, 8(1), 43-47。,肿瘤综合治疗电子杂志,8(1), 43-47

朱华, 杨志*. 肿瘤新型放射性药物的研发与应用,中华核医学与分子影像杂志,41(10):577-579

王帅亮,朱华,杨志*. T细胞核医学分子成像策略在CAR-T免疫治疗中的应用,中华核医学与分子影像杂志,41(3)175-179

蒋金泉, 李丹, 刘特立, 徐晓霞, 夏雷, 郭晓轶, 朱华*, 杨志. 肿瘤免疫治疗PD-L1靶向新型PET分子探针68Ga-WL12研制、质控及初步生物学研究,中国医学影像技术,37(1), 79-83

朱华、张锦明、杜进、杨敏、唐刚华、程登峰、李宸、李国祥、李子颖、徐宇平、李亚明*、杨志*。中国固体靶放射性核素制备与应用共识,中华核医学与分子影像杂志,40(9),545-548

任亚楠, 刘特立, 李大鹏, 李慧, 丁缙, 朱华*, 杨志*. 功能化PSMA在前列腺癌核素靶向治疗中的研究进展,肿瘤防治研究,47 (12): 975-979

熊荷蕾,韩梅,李丹,朱华*,杨志. PET核素药物临床应用流程中质量控制要点的国内外对比—以68Ga为例的系列质控,肿瘤综合治疗电子杂志,6(3), 64-68

王淑静, 徐晓霞, 周欣, 刘特立, 李囡, 朱华*, 杨志*. 肿瘤免疫治疗PD-1/PD-L1靶向核素分子探针的研究进展[J],肿瘤防治研究,47(01): 70-76

刘特立,刘辰,张羽琪,邓虞娇,朱华*,杨志*。 前列腺特异性膜抗原PET/CT特异性分子显像在非前列腺癌诊断中的应用,肿瘤防治研究,46(11), 1022-1025

刘特立,刘辰,夏雷,郭晓轶,蒋金泉,朱华,李囡,王铁*,杨志*。PSMA分子探针Al18F-PSMA-BCH的制备及其临床应用,中华核医学与分子影像杂志,39(12), 743-747

蒋金泉, 刘特立, 夏雷, 朱华*, 杨志. 小分子肽免疫检查点抑制剂PET探针引导肿瘤免疫治疗新进展,国际肿瘤学杂志,46(8), 449-452

《核医学与分子影像》, 主译, 北京大学医学出版社, 2022.6

北京市“首都前沿学术成果”奖, “首都前沿学术成果”奖, 第1完成人, 北京市, 2022.12

2019年度“优秀团队人才奖”, 优秀团队人才奖, 第1完成人, 北京肿瘤医院, 2020.1

2020年度教学评优,“教学管理先进个人”, 教学管理先进个人, 第1完成人, 北京大学肿瘤医院, 2020.12

2020年度教学评优,影像教研室“教学优秀集体”, 教学优秀集体, 第1完成人, 北京大学肿瘤医院, 2020.12

2021.11.12 中日韩放射性药物大会,CJKSRS 2021 “Young Investigator Award”, Young Investigator Award, 第2完成人, 中日韩放射性药物大会, 2021.11

2021第三届首都转化医学创新大赛 “肿瘤免疫治疗新型LMW-PET 探针临床转化”优秀项目奖, 肿瘤免疫治疗新型LMW-PET 探针临床转化, 第1完成人, 北京市卫生健康委员会, 2021.12

2020年 第十五届全国放射性药物与标记化合物会议《新型PET核素免疫成像探针开发及临床转化》大会报告, 《新型PET核素免疫成像探针开发及临床转化》大会报告, 第1完成人, 中国原子能科学研究院, 2020.11

“前哨淋巴结特异性探针的研制及临床转化”2019年北京医学科技奖三等奖, 2019年北京医学科技奖三等奖, 第1完成人, 北京医学会, 2020.7

“PD1/PDL1免疫治疗新型低分子量肽PET探针临床转化”2021年第三届首都转化医学创新大赛,优秀项目奖, 2021年第三届首都转化医学创新大赛,优秀项目奖, 第1完成人, 北京市卫生健康委员会, 2021.12

2021年度全国颠覆性技术创新大赛“靶向血管紧张素2的新型核素诊疗技术”,优秀项目, 2021年度全国颠覆性技术创新大赛“靶向血管紧张素2的新型核素诊疗技术”,优秀项目, 第1完成人, 科技部火炬中心, 2021.12

2021年12月,中国核学会“优秀工作者”, 2021年12月,中国核学会“优秀工作者”, 第1完成人, 中国核学会, 2021.12

北京大学实验室工作“先进个人”, 北京大学实验室工作“先进个人”, 第1完成人, 北京大学, 2022.8

北京大学“2022 年度实验室工作先进集体称号”, 2022 年度实验室工作先进集体称号, 第1完成人, 北京大学, 2022.8

核素探针研发及临床转化, 课题负责人, 2024.1.1~2026.12.31, 国家级人才计划青年项目

基于生物正交-胃癌黏蛋白靶点可视化早诊及核素探针临床转化的研究, 课题负责人, 2024.1.1~2026.12.31, 国家自然科学基金重大研究计划重点项目

“蛋白质丢失性肠病(PLE)成像PET 探针研发与临床转化”, 课题负责人, 2023.1.1~2024.12.31, 2022年度北京大学肿瘤医院临床研究青年基金

5T4 靶向纳米抗体 PET 探针研制及肿瘤临床转化, 课题负责人, 2023.6.1~2024.12.31, 北京大学肿瘤医院临床研究联合基金-Zai 基金

TCP-1-L-NOTA-18FAl探针在结直肠肿瘤小鼠模型中的PET/CT肿瘤成像, 课题负责人, 2021.11.1~2022.2.28, 中国医学科学科学院药物研究所,

ACE靶向核医学显像探针的构建及临床转化, 课题负责人, 2023.1.1~2024.12.31, 北京市科学技术委员会“2022年北京市科技新星计划 交叉合作课题”

新型免疫靶点特异性LMW-PET探针临床转化, 课题负责人, 2022.1.1~2022.11.30, 北京大学肿瘤医院、学科发展-科创项目

下一代”PET 核素探针的研发及指导肿瘤免疫治疗的临床转化, 课题负责人, 2020.1.1~2021.12.31, 北京市百千万人才工程培养经费资助A类

PET/光学探针监测肿瘤免疫联合抗血管生成治疗的分子影像策略, 课题负责人, 2022.1.1~2025.12.31, 国家自然科学基金面上项目

PD1/PDL1 免疫治疗新型低分子量肽 PET 探针临床转化, 课题负责人, 2022.1.1~2024.12.31, 北京市卫生健康委员会首都卫生发展科研专项

生物学可控的Her-MNP纳米平台的构建、评价及分子显像的研究。, 课题负责人, 2017.1.1~2020.12.31, 国家自然科学基金面上项目 (No. 81671733)

新型64Cu核素的制备及64Cu-DOTA-TATE探针在NET诊疗的应用。, 课题负责人, 2017.1.1~2019.12.31, 北京市科学技术委员会“2017年北京市科技新星计划”(xx2017016)。

新型固体靶PET核素探针在胃肠肿瘤的转化研究, 课题负责人, 2018.1.1~2020.12.31, 北京市委组织部 2017000021223ZK33

国家重点研发计划“重大慢性非传染性疾病防控研究”专项。“胃癌靶向治疗新技术研究”项目, 参加者, 2017.7.1~2020.12.31, 科技部,2017YFC1308903

HER2靶向PET探针的构建及其指导肿瘤精准诊疗的临床转化。, 课题负责人, 2019.1.8~2019.12.8, 北京市自然科学基金 京津冀基础研究合作专项。(H2018206600)

研究生招生计划
招生年度 招生专业 学位级别 学位类型 研究方向 选拔方式 操作
2025 影像医学与核医学 博士 科学学位 新型核医学分子探针的研究与临床转化 申请考核制

社会任职

  • 全国高等院校本科临床医学专业国家化教育“十三五”规划教材《核医学》编委
  • 中国核学会放射性药物分会秘书长

学习、工作经历

  • 2021.8.1~,北京大学肿瘤医院 研究员
  • 2015.8.1~2021.7.31,北京大学肿瘤医院核医学科副研究员
  • 2014.11.1~2015.11.1,美国斯坦福大学药学院放射治疗系访问学者
  • 2011.8.1~2015.7.1,北京大学肿瘤医院核医学科助理研究员
  • 2007.9.1~2011.7.1,中国科学院上海应用物理研究所(硕博连读)理学博士