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Emerging strategies of cell and gene therapy targeting tumor immune microenvironment,Clinical Cancer Research,2294-2308

Circulating tumor dna predicts clinical benefits of immune checkpoint blockade in her2-negative patients with advanced gastric cancer,Gastric Cancer,no. 5, 872-885

Cheng Zhang#, Xi Jiao, Lin Shen*. From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space,Cancer Cell,2023 Oct 19:S1535-6108(23)00361-6

Fangli Jiang#, Keren Jia#, Yang Chen, Congcong Ji, Xiaoyi Chong, Zhongwu Li, Feilong Zhao, Yuezong Bai, Sai Ge, Jing Gao, Xiaotian Zhang, Jian Li*, Lin Shen*, Cheng Zhang*. ANO1-mediated inhibition of cancer ferroptosis confers immunotherapeutic resistance through recruiting cancer-associated fibroblasts,Advanced Science,2023 Jun 21;e2300881.

Cheng Zhang#, Xiaoyi Chong#, Fangli Jiang#, Jing Gao*, Yang Chen, Keren Jia, Meng Fan, Xuan Liu, Jin An, Jian Li, Xiaotian Zhang*, Lin Shen*. Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer.,Journal of Extracellular Vesicles,2022 Apr;11(4):e12209

Qihang Zhong#, Honglei Chu#, Guopeng Wang#, Cheng Zhang#, Rong Li, Fusheng Guo, Xinlu Meng, Xiaoguang Lei, Youli Zhou, Ruobing Ren, Lin Tao, Ningning Li, Ning Gao, Yuan Wei*, Jie Qiao*, Jing Hang*. Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2,Cell Discovery,(2022) 8:137

Yang Chen#, Keren Jia#, Yu Sun#, Cheng Zhang#, Yilin Li, Li Zhang, Zifan Chen, Jiangdong Zhang, Yajie Hu, Jiajia Yuan, Xingwang Zhao, Yanyan Li, Jifang Gong, Bin Dong, Xiaotian Zhang, Jian Li, Lin Shen*. Predicting response to immunotherapy in gastric cancer via multi-dimensional analyses of the tumour immune microenvironment.,Nature Communications,(2022) 13:4851

Keren Jia#, Yang Chen#, Jiajia Yuan1, Changsong Qi, Yanyan Li, Jifang Gong, Yajie Hu, Yu Sun, Jing Gao, Xiaotian Zhang, Jian Li, Cheng Zhang*, Lin Shen*. Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer,BMC Medicine,2022 Jul 11;20(1)

Cheng Zhang#, Jing Yang#, Yang Chen#, Fangli Jiang, Haiyan Liao, Xiang Liu, Yuan Wang, Guanyi Kong, Xiaotian Zhang, Jian Li, Jing Gao#, Lin Shen*. miRNAs derived from plasma small extracellular vesicles predict organo-tropic metastasis of gastric cancer,Gastric Cancer,2022 Mar;25(2):360-374

Mengqi Zhang#, Beifang Li#, Haiyan Liao, Zuhua Chen, Wenwen Huang, Jing Yang, Sai Ge, Zhongwu Li, Lin Shen, Cheng Zhang*, Jing Gao*. Targeting HER3 or MEK overcomes acquired Trastuzumab resistance in HER2-positive gastric cancer-derived xenograft.,Cell Death Discovery,2022 Dec 3;8(1):478

Fangli Jiang#, Zhening Zhang#, Xiaoyi Chong, Lin Shen, Meng Fan, Xuan Liu, Jin An, Zhi Peng*, Cheng Zhang*. Extracellular vesicle-derived protein file from peripheral blood predicts immune-related adverse events in gastric cancer patients receiving immunotherapy,Cancers,2022 Aug 28;14(17):4167

Shujing Wang#, Changsong Qi#, Jin Ding#, Dan Li, Miao Zhang, Congcong Ji, Fangli Jiang, Fei Teng, Jie Yu, Xueming Qian, Feng Wang, Lin Shen, Jing Gao*, Zhi Yang*, Cheng Zhang*, Hua Zhu*. First-in-human CLDN18.2 functional diagnostic pet imaging of digestive system neoplasms enables whole-body target mapping and lesion detection,Eur J Nucl Med Mol Imaging,2023 Apr 26. doi: 10.1007/s00259-023-06234-z

Qian Guo, Chuanke Zhao, Xiangyu Gao, Lixin Ding, Pei Wang, Ya'nan Ren, Xingguo Hou, Yuan Yao, Cheng Zhang*, Xianteng Yang*, Zhi Yang*, Hua Zhu*. One-Minute Iodine Isotope Labeling Technology Enables Noninvasive Tracking and Quantification of Extracellular Vesicles in Tumor Lesions and Intact Animals,molecular pharmaceutics,2023 May 22. doi: 10.1021/acs.molpharmaceut.3c00299

Changsong Qi, Mingyang Ma, Kaijie Liang, Chang Liu, Jiarui Li, Yakun Wang, Dan Liu, Miao Zhang, Xiaoyi Chong, Fangli Jiang, Shengde Liu, Zizhen Zhang, Congcong Ji, Yuezong Bai, Meng Fan, Chuanhui Han, Xiaotian Zhang, Jifang Gong, Jian Li, Lin Shen, Cheng Zhang. Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers,Nature Communications,2026 in press

中华医学科技奖一等奖, 消化道肿瘤精准治疗研究体系的建立与应用, 第5完成人, 中华医学会, 2022.3

北京市科技新星, 北京市科技新星, 第1完成人, 北京市科委, 2024.8

消化道肿瘤精准治疗与转化研究, 中国抗癌协会科技奖一等奖, 第5完成人, 中国抗癌协会, 2025.10

成纤维细胞通过FAK信号通路驱动胃癌腹膜转移的机制研究, 课题负责人, 2026.1.1～2029.12.30, 国家自然科学基金面上项目

ANO1介导的铁死亡抑制信号在肿瘤细胞-肿瘤相关成纤维细胞之间双向传递从而诱导胃癌免疫治疗耐药的功能机制研究, 课题负责人, 2023.3.1～2027.12.31, 国家自然科学基金面上项目

外泌体诱导消化道肿瘤CLDN18.2-CAR-T细胞治疗耐药的原理和干预策略研究, 课题负责人, 2024.9.1～2027.12.30, 北京市科技新星

用于治疗消化系统肿瘤的ANO1靶向CAR-T细胞疗法的建立与优化, 课题负责人, 2024.9.1～2027.12.30, 北京市科技新星交叉项目

指导胃癌免疫治疗的外泌体多模态液体活检模型构建和功能机制研究, 课题负责人, 2024.1.1～2027.12.30, 北京市自然科学基金创新联合项目

消化道肿瘤免疫治疗耐药相关的肿瘤微环境关键“金属-代谢-免疫”特征研究, 课题负责人, 2024.1.1～2027.12.31, 北京市自然科学基金重点研究专题

YARS通过E2F1及PI3K-Akt信号通路促进胃癌恶性进展的机制研究, 课题负责人, 2019.1.1～2021.12.21, 国家自然科学基金青年项目

KDM5基因家族在胃癌中的作用机制、小分子抑制剂开发及联合免疫治疗的研究, 课题负责人, 2022.1.1～2022.12.31, 北京大学临床医学+X青年专项

血浆外泌体蛋白组分指导胃癌精准治疗的临床应用前景探索和机制研究, 课题负责人, 2022.1.1～2023.3.31, 北京大学肿瘤医院科学研究基金

以膜蛋白和miRNA为代表的血浆外泌体组分影响胃癌免疫治疗的作用研究和机制探索, 课题负责人, 2021.1.1～2022.12.31, 北京市医院中心，“青苗”计划