学术论文 | 研究方向 | 科研项目
Wenjie Wong, Baozhen Zhang, Dajun Deng*. P16INK4A Drives RB1 Degradation by UTP14A-Catalyzed K810 Ubiquitination,iSCIENCE,27:110882
Zhiyuan Fan#, Jing Zhou#, Yuan Tian, Yu Qin, Zhaojun Liu, Liankun Gu, Sanford M. Dawsey, Wenqiang Wei*, Dajun Deng*. Somatic CDKN2A Copy Number Variations are associated with the prognosis of Esophageal Squamous Cell Dysplasia.,Chinese Medical Journal,
Xuehong Zhang#, Paiyun Li#, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang*, Dajun Deng*. Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts,Chinese Medical Journal,
Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D*. Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1,Mol Oncol,2022 Sep;16(17):3192-3209. doi: 10.1002/1878-0261.13292. Epub 2022 Jul 28.
Abin You#, Wei Tian*, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng*. TTC22 promotes m6A-mediated WTAP expression and colon cancer metastasis in an RPL4 binding-dependent pattern.,Oncogene,41(32):3925-2938
Wanru Ma#, Juanli Qiao#, Jing Zhou, Liankun Gu, Dajun Deng*. Characterization of Novel LncRNA P14AS as a Protector of ANRIL through AUF1 Binding in Human Cells.,Molecular Cancer,19:42
Meiyi Xiang, Wensu Liu, Abin You, Wei Tian, Dajun Deng*. RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy,Epigenomics,12(9):801-809
Yu Qin, Jing Zhou, Dongmei Lin, Dajun Deng*, Wenqing Wei*. Evaluation the Impact of Intratumoral Heterogeneity of Esophageal Cancer on Pathological Diagnosis and P16 Methylation and the Representativity of Endoscopic Biopsy.,Frontiers in Oncology,11:683876
Ge Zhang, Meiyi Xiang, Liankun Gu, Jing Zhou, Baozhen Zhang, Wei Tian, Dajun Deng* The Essential Role of TTC28 in Maintaining Chromosomal Stability via HSPA8 Chaperone-Mediated Autophagy,PNAS,121(50):e2409447121
Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu, Jing Zhou, Wei Tian*, Dajun Deng*. LncRNA miR663AHG represses the development of colon cancer in a miR663a expression-dependent manner.,Cell Death Discovery,9:220
Nan Ding, Abin You, Wei Tian, Liankun Gu, Dajun Deng*. Chidamide increases the sensitivity of non-small cell lung cancer to crizotinib by decreasing c-MET mRNA methylation.,International Journal of Biological Sciences,16:2595-2611
Paiyun Li#, Ying Gan#, Sisi Qin, Xiao Han, Chenghua Cui, Zhaojun Liu, Jing Zhou, Liankun Gu, Zhe-ming Lu, Baozhen Zhang*, Dajun Deng* DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells,Epigenetics,15(6-7):618-631
Juanli Qiao#, Yuan Tian#, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing*, Dajun Deng*. CDKN2A deletion leading to hematogenous metastasis of human gastric carcinoma,Frontiers in Oncology,11:801219
Zhuoqi Li; Juanli Qiao; Wanru Ma; Jing Zhou; Liankun Gu; Dajun Deng*; Baozhen Zhang*. P14AS upregulates gene expression in the CDKN2A/2B locus via competitive binding to PcG protein CBX7,Frontiers in Cell and Developmental Biology,doi: 10.3389/fcell.2022.993525
Yuan Tian#,Jing Zhou#, Juanli Qiao, Zhaojun Liu, Liankun Gu, Baozhen Zhang, Youyong Lu, Rui Xing*, Dajun Deng*. Detection of Somatic Copy Number Deletion of the CDKN2A Gene by Quantitative Multiplex PCR for Clinical Practice,Frontiers in Oncology,12:1038380
细胞核变形与p16 DNA甲基化协同促进CDKN2A基因拷贝数缺失, 课题负责人, 2024.1.1~2027.12.31, 国家自然科学基金
NRF1-EZH2-DNMT1信号轴的发现及其在肿瘤表观遗传变异形成中的作用, 课题负责人, 2021.1.1~2024.12.31, 国家自然科学基金委员会
P16基因甲基化DNA氧化位点的功能及其临床应用潜能, 课题负责人, 2017.1.1~2020.12.31, 国家自然科学基金面上项目/81672770
一种新的P16基因增强子反义链lncRNA P16AS的功能与肿瘤发生发展, 课题负责人, 2017.1.1~2019.12.31, 国家自然科学基金重大科学计划培育项目/91640108
社会任职
- 中国抗癌协会肿瘤病因学专业委员会荣誉主任委员(2024-)
- 《Gastric Cancer》Editorial Board Member (2013-)
学习、工作经历
- 2014.3.1~2017.11.30,教育部重点实验室执行副主任
- 2003.7.1~2025.6.30,教授
- 2001.4.15~2002.3.30,Visiting Research Associate, University of Virginia Health Science Center
- 1998.6.3~2021.1.31,研究员、病因学研究室主任
- 1993.7.1~1998.6.30,病因室副研究员、研究室主任