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导师基本信息

  • 姓名:邓大君
  • 性别:
  • 民族:汉族
  • 科室:病因学研究室
  • 职称:研究员,教授
  • 专业:肿瘤学
  • E-MAIL: dengdajun@bjmu.edu.cn

学术论文 | 研究方向 | 科研项目

Xuehong Zhang#, Paiyun Li#, Ying Gan, Shengyan Xiang, Liankun Gu, Jing Zhou, Xiaorui Zhou, Peihuang Wu, Baozhen Zhang*, Dajun Deng*. Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts,Chinese Medical Journal,

Tian W, Yuan H, Qin S, Liu W, Zhang B, Gu L, Zhou J, Deng D*. Kaiso phosphorylation at threonine 606 leads to its accumulation in the cytoplasm, reducing its transcriptional repression of the tumour suppressor CDH1,Mol Oncol,2022 Sep;16(17):3192-3209. doi: 10.1002/1878-0261.13292. Epub 2022 Jul 28.

Abin You#, Wei Tian*, Hongfan Yuan, Liankun Gu, Jing Zhou, Dajun Deng*. TTC22 promotes m6A-mediated WTAP expression and colon cancer metastasis in an RPL4 binding-dependent pattern.,Oncogene,41(32):3925-2938

Wanru Ma#, Juanli Qiao#, Jing Zhou, Liankun Gu, Dajun Deng*. Characterization of Novel LncRNA P14AS as a Protector of ANRIL through AUF1 Binding in Human Cells.,Molecular Cancer,19:42

Meiyi Xiang, Wensu Liu, Abin You, Wei Tian, Dajun Deng*. RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy,Epigenomics,12(9):801-809

Yu Qin, Jing Zhou, Dongmei Lin, Dajun Deng*, Wenqing Wei*. Evaluation the Impact of Intratumoral Heterogeneity of Esophageal Cancer on Pathological Diagnosis and P16 Methylation and the Representativity of Endoscopic Biopsy.,Frontiers in Oncology,11:683876

Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu, Jing Zhou, Wei Tian*, Dajun Deng*. LncRNA miR663AHG represses the development of colon cancer in a miR663a expression-dependent manner.,Cell Death Discovery,9:220

Nan Ding, Abin You, Wei Tian, Liankun Gu, Dajun Deng*. Chidamide increases the sensitivity of non-small cell lung cancer to crizotinib by decreasing c-MET mRNA methylation.,International Journal of Biological Sciences,16:2595-2611

Paiyun Li#, Ying Gan#, Sisi Qin, Xiao Han, Chenghua Cui, Zhaojun Liu, Jing Zhou, Liankun Gu, Zhe-ming Lu, Baozhen Zhang*, Dajun Deng* DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells,Epigenetics,15(6-7):618-631

Juanli Qiao#, Yuan Tian#, Xiaojing Cheng, Zhaojun Liu, Jing Zhou, Liankun Gu, Baozhen Zhang, Lianhai Zhang, Jiafu Ji, Rui Xing*, Dajun Deng*. CDKN2A deletion leading to hematogenous metastasis of human gastric carcinoma,Frontiers in Oncology,11:801219

Zhuoqi Li; Juanli Qiao; Wanru Ma; Jing Zhou; Liankun Gu; Dajun Deng*; Baozhen Zhang*. P14AS upregulates gene expression in the CDKN2A/2B locus via competitive binding to PcG protein CBX7,Frontiers in Cell and Developmental Biology,doi: 10.3389/fcell.2022.993525

Yuan Tian#,Jing Zhou#, Juanli Qiao, Zhaojun Liu, Liankun Gu, Baozhen Zhang, Youyong Lu, Rui Xing*, Dajun Deng*. Detection of Somatic Copy Number Deletion of the CDKN2A Gene by Quantitative Multiplex PCR for Clinical Practice,Frontiers in Oncology,12:1038380

细胞核变形与p16 DNA甲基化协同促进CDKN2A基因拷贝数缺失, 课题负责人, 2024.1.1~2027.12.31, 国家自然科学基金

NRF1-EZH2-DNMT1信号轴的发现及其在肿瘤表观遗传变异形成中的作用, 课题负责人, 2021.1.1~2024.12.31, 国家自然科学基金委员会

P16基因甲基化DNA氧化位点的功能及其临床应用潜能, 课题负责人, 2017.1.1~2020.12.31, 国家自然科学基金面上项目/81672770

一种新的P16基因增强子反义链lncRNA P16AS的功能与肿瘤发生发展, 课题负责人, 2017.1.1~2019.12.31, 国家自然科学基金重大科学计划培育项目/91640108

社会任职

  • 中国抗癌协会肿瘤病因学专业委员会前主任委员(2022-)
  • 《Gastric Cancer》Editorial Board Member (2013-)

学习、工作经历

  • 2014.3.1~2017.11.30,教育部重点实验室执行副主任
  • 2003.7.1~2025.6.30,教授
  • 2001.4.15~2002.3.30,Visiting Research Associate, University of Virginia Health Science Center
  • 1998.6.3~2021.1.31,研究员、病因学研究室主任
  • 1993.7.1~1998.6.30,病因室副研究员、研究室主任